New pill shows promise for Hard-to-Treat neuroendocrine tumors

NCT ID NCT03600233

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial is testing an oral drug called CVM-1118 in 34 people with advanced neuroendocrine tumors that have not responded to standard treatments. The drug aims to slow tumor growth and improve disease control. Participants take the pill twice daily, with a possible dose increase if tolerated.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CVM-1118 (also called TRX-818), an oral anti-cancer drug

What this could lead to

If successful, this could provide a new treatment option for people with advanced neuroendocrine tumors that have stopped responding to standard therapies.

What could go wrong

This is a small, early-phase trial with only 34 participants, so results may not apply to everyone. The drug may not shrink tumors or improve survival, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Adenoma, Islet Cell digestive system neuroendocrine neoplasm lung neuroendocrine neoplasm neoplasm neuroendocrine carcinoma neuroendocrine neoplasm pancreatic neuroendocrine tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Chang Gung Memorial Hospital, KaoHsiung

    Kaohsiung City, Taiwan

  • Chang Gung Memorial Hospital, LinKou

    Taoyuan City, Taiwan

  • China Medical University Hospital

    Taichung, Taiwan

  • Kaohsiung Medical University Hospital

    Kaohsiung City, Taiwan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • New Taipei Municipal TuCheng Hospital

    New Taipei City, Taiwan

  • Taichung Veterans General Hospital

    Taichung, Taiwan

  • Taipei Veterans General Hospital

    Taipei, Taiwan