PANCREATIC NEUROENDOCRINE TUMOR

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This study looks at whether removing most of the visible tumors (debulking surgery) in people with stage 4 pancreatic neuroendocrine tumors (pan-NET) can help them live longer and feel better compared to standard medical treatments alone. About 200 adults with slow-growing, advan…

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) in 21 adults with advanced endocrine tumors, such as adrenal, thyroid, or pancreatic cancers, that have not responded to standard treatments. The vaccine is designed to train the immune system to attack each pati…

This study looks at whether giving two chemotherapy drugs (capecitabine and temozolomide) after surgery can stop high-risk pancreatic neuroendocrine tumors from coming back. About 141 people who had their tumor removed will either get the chemo or just be watched. The goal is to …

This study tests a drug called belzutifan in people with advanced cancers linked to a protein called HIF-2α, including rare tumors like pheochromocytoma/paraganglioma and VHL disease. The goal is to see if the drug can shrink tumors or stop them from growing. About 322 participan…

This study tests an experimental drug called ESK981 in people with advanced pancreatic cancer, certain neuroendocrine tumors, or neuroendocrine prostate cancer. Participants take ESK981 capsules in a 5-days-on, 2-days-off cycle. The main goal is to see if the drug can keep the ca…

This study is testing a new blood test that looks at tiny pieces of DNA to find pancreatic neuroendocrine tumors early and tell them apart from other pancreatic tumors. Researchers will study 1,000 adults who have not yet had treatment. The goal is to see how accurate the test is…

This study tests an artificial intelligence system that analyzes contrast-enhanced CT scans to help doctors decide the best next step for people with suspected pancreatic diseases. The AI will classify patients into three groups: immediate treatment, close monitoring, or routine …

This study compares two surgical methods for removing part of the pancreas and nearby organs in people with pancreatic or related cancers. About 90 adults will be randomly assigned to either laparoscopic (keyhole) or open surgery. The goal is to see which approach leads to fewer …