PANCREATIC NEUROENDOCRINE TUMOR

This study looks at how well the drug cabozantinib works and how safe it is for adults with neuroendocrine tumors (NETs) that have continued to grow after at least one prior treatment. About 150 participants in Germany and Austria will be followed during their routine care. Docto…

This phase 2 study tests belzutifan, a daily pill that blocks a protein called HIF-2α, in people with advanced rare cancers like pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, VHL disease-associated tumors, and certain other solid tumors. The goal is to see if …

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) for people with advanced endocrine tumors like adrenal cancer, medullary thyroid cancer, and pancreatic neuroendocrine tumors who have no standard treatment left. The vaccine is made to target unique mutations in…

This study is testing a procedure called EUS-guided radiofrequency ablation (RFA) for people with pancreatic tumors who are not candidates for surgery. The procedure uses a thin needle passed through an endoscope to deliver heat directly to the tumor. Researchers want to see if i…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…

This study compares two types of Whipple surgery for people with pancreatic or nearby cancers: the traditional open surgery and a newer keyhole (laparoscopic) approach. About 90 adults with resectable tumors will be randomly assigned to one of the two procedures. The goal is to s…

This study looks at people with stage 4 pancreatic neuroendocrine tumors (pan-NET) that have spread. It compares two approaches: having surgery to remove as much tumor as possible (plus optional drug treatment) versus drug treatment alone. The goal is to see which helps people li…

This study looks at whether giving two chemotherapy drugs (capecitabine and temozolomide) after surgery can prevent or delay the return of high-risk pancreatic neuroendocrine tumors. About 141 people who have had their tumor removed will be randomly assigned to receive the drugs …

This study tests a new radioactive imaging agent called 68Ga-HA-DOTATATE to see if it can safely and accurately detect neuroendocrine tumors using PET/CT scans. About 600 people with known or suspected tumors will receive the agent and be followed for one year. The goal is to imp…

This study is testing a new blood test that looks at fragments of DNA to find pancreatic neuroendocrine tumors early and tell them apart from other pancreatic tumors. Researchers will collect blood from 1,000 adults with different types of pancreatic tumors to see how accurate th…

This study tests an artificial intelligence (AI) system that analyzes contrast-enhanced CT scans to help diagnose and manage pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitoring, or routine follow-up. Researchers will…

This study aims to better understand why some people experience dangerously low blood sugar (hypoglycemia), especially after fasting. Researchers will admit 1,500 adults to the NIH Clinical Center for controlled fasting and a series of blood tests to measure insulin and other fac…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This study looks at tiny particles called exosomes, which carry proteins and genetic material between cells. Researchers will collect blood and tissue from 181 people with pancreatic cancer or noncancerous pancreatic disease to compare exosome activity. The goal is to understand …

This study tests a new radioactive tracer called [18F]FTT to see how well it lights up pancreatic neuroendocrine tumors on a PET scan. Twelve adults with advanced tumors will receive one injection and have a whole-body scan. The goal is to measure tumor activity and compare it wi…

This study explores whether a special PET/CT scan using a tracer called [18F]PT2385 can detect a protein (HIF2α) that helps kidney cancers grow. About 35 adults with kidney cancer or a genetic condition called VHL syndrome will receive the scan, and results will be compared with …