New hope for rare lung cancer: targeted drug trial launches

NCT ID NCT07185997

Recruiting now Disease control Sponsor: ArriVent BioPharma, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study tests a new drug, firmonertinib, against two standard treatments for people with advanced non-small-cell lung cancer that has certain rare genetic changes (EGFR PACC mutations). About 480 participants who have not had prior treatment for advanced disease will be randomly assigned to receive firmonertinib or a standard drug. The goal is to see if firmonertinib can better delay cancer growth or improve response rates.

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Conditions

The condition(s) this trial relates to.

bronchial neoplasm lung neoplasm non-small cell lung carcinoma respiratory tract neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED NON-SMALL CELL LUNG CANCER EGFR P-LOOP AND ALPHA C-HELIX COMPRESSING EGFR PACC EGFR UNCOMMON MUTATIONS METASTATIC NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Alberta Health Services, Tom Baker Cancer Centre
RECRUITING

Calgary, Alberta, T2N 4N2, Canada
Anatalya Province
RECRUITING

Antalya, 07050, Turkey (Türkiye)
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Athens Medical Center S.A., European Interbalkan Medical Center
RECRUITING

Thessaloniki, 570 01, Greece
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
BC Cancer Vancouver Centre
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Blacktown Cancer and Haematology Centre
RECRUITING

Blacktown, New South Wales, 2148, Australia
Brampton Civic Hospital, William Osler Health Centre
RECRUITING

Brampton, Ontario, L6R 3J7, Canada
Centre Francois Baclesse
RECRUITING

Caen, Calvados, 14076, France
Centre Leon-Berard
RECRUITING

Lyon, 69373, France
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, Jeollanam-do, 58128, South Korea
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Chulabhorn Hospital
RECRUITING

Lak Si, Bangkok, 10210, Thailand
Curie Oncology (Farrer)
RECRUITING

Singapore, 217562, Singapore
Faculty of Medicine Vajira Hospital, Navamindradhiraj University
RECRUITING

Bangkok, 10300, Thailand
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
GenesisCare North Shore Health Hub
RECRUITING

St Leonards, New South Wales, 2065, Australia
Gulhane Training and Research Hospital
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Henry Dunant Hospital Center
RECRUITING

Athens, 115 26, Greece
Henry Ford Cancer Institute
RECRUITING

Detroit, Michigan, 48202, United States
Hopital Larrey
RECRUITING

Toulouse, Occitanie, 31059, France
Hopital Nord Guilaume-et-Rene-Laennec CHU de Nantes
RECRUITING

Saint-Herblain, 44093, France
Hospices Civil de Lyon
RECRUITING

Bron, Auvergne-Rhône-Alpes, 69500, France
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, WP Kuala Lumpur, 50586, Malaysia
Hospital Nord de Marseille
RECRUITING

Marseille, Bouches-du-Rhone, 13915, France
Hospital QuironSalud Malaga
RECRUITING

Málaga, 29004, Spain
Hospital Universitari Son Espases
RECRUITING

Palma, Balearic Islands, 07120, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
Humanity and Health Clinical Trial Centre
RECRUITING

Central, Hong Kong
Hyogo Cancer Center
RECRUITING

Akashi-shi, Hyōgo, 673-8558, Japan
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Insitut de Canderologie d I'Ouest
RECRUITING

Saint-Herblain, 44805, France
Istinye University Bahcesehir Liv Hospital
RECRUITING

Istanbul, 34517, Turkey (Türkiye)
Istituto Europeo di Oncologia (IEO)
RECRUITING

Milan, 20141, Italy
Kaiser Permanente Medical Center
RECRUITING

Vallejo, California, 94589, United States
Kangbuk Samsung Hospital
RECRUITING

Seoul, 03181, South Korea
Kansai Medical University Hospital
RECRUITING

Hirakata-shi, Osaka, 573-1191, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Kurume University Hospital
RECRUITING

Kurume-Shi, Fukuoka, 830-0011, Japan
Kyung Hee University Hospital
RECRUITING

Seoul, 02447, South Korea
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Mahidol University - Siriraj Hospital
RECRUITING

Bangkoknoi, Bangkok, 10700, Thailand
Medical Park Florya Hospital
RECRUITING

Istanbul, 34295, Turkey (Türkiye)
Miyagi Cancer Center
RECRUITING

Natori-shi, Miyagi, 981-1293, Japan
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
National Hospital Organization Hokkaido Cancer Center
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan
National Taiwan University Cancer Center
RECRUITING

Taipei, 106, Taiwan
Niigata Cancer Center Hospital
RECRUITING

Niigata, Niigata, 951-8566, Japan
Nippon Medical School Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8603, Japan
Northwell Health/R.J. Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States
Ohio State University Hospitals
RECRUITING

Columbus, Ohio, 43210, United States
OncoCar Cancer Centre
RECRUITING

Petaling Jaya, Selangor, 47810, Malaysia
Prince of Songkla Hospital
RECRUITING

Hat Yai, Changwat Songkhla, 90110, Thailand
Princess Margaret Cancer Centre - University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence St. Joseph Hospital
RECRUITING

Orange, California, 92868, United States
Queen Mary Hospital
RECRUITING

Hong Kong, 000000, Hong Kong
SOC Oncologia Medica e dei Tumori Immuno-correlati
RECRUITING

Aviano, 33081, Italy
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Shenandoah Oncology, P.C.
RECRUITING

Winchester, Virginia, 22601, United States
St. Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Swedish Cancer Institute
RECRUITING

Edmonds, Washington, 98026, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tan Tok Seng Hospital
RECRUITING

Singapore, 308433, Singapore
Texas Oncology
RECRUITING

Dallas, Texas, 75246, United States
The Catholic University of Korea, St. Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
The Christie NHS Foundation Trust
RECRUITING

Manchester, England, M20 4BX, United Kingdom
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Thoracic General Hospital of Athens I Sotiria
RECRUITING

Thessaloniki, 570 01, Greece
Tokyo Metropolitan Komagome Hospital
RECRUITING

Bunkyō-Ku, Tokyo, 113-8677, Japan
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University College London Hospitals NHS Foundation Trust
RECRUITING

London, England, NW1 2PG, United Kingdom
University General Hospital Attikon - General Hospital of West Attica H AGIA VARVARA
RECRUITING

Athens, 124 62, Greece
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Colorado Health
RECRUITING

Aurora, Colorado, 80045, United States
University of Illinois Hospital and Health Sciences Systems
RECRUITING

Chicago, Illinois, 60612, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States

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