New hope for rare lung cancer: targeted drug trial launches
NCT ID NCT07185997
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 23 times
Summary
This study tests a new drug, firmonertinib, against two standard treatments for people with advanced non-small-cell lung cancer that has specific rare genetic changes (EGFR PACC mutations). About 480 participants who have not had prior treatment for advanced disease will be randomly assigned to receive firmonertinib or a standard drug. The goal is to see if firmonertinib can better delay cancer growth or improve response rates.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aichi Cancer Center
RECRUITINGNagoya, Aichi-ken, 464-8681, Japan
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
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Athens Medical Center S.A., European Interbalkan Medical Center
RECRUITINGThessaloniki, 570 01, Greece
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Austin Health
RECRUITINGHeidelberg, Victoria, 3084, Australia
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Blacktown Cancer and Haematology Centre
RECRUITINGBlacktown, New South Wales, 2148, Australia
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Chonnam National University Hwasun Hospital
RECRUITINGHwasun, Jeollanam-do, 58128, South Korea
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Chris O'Brien Lifehouse
RECRUITINGCamperdown, New South Wales, 2050, Australia
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Curie Oncology (Farrer)
RECRUITINGSingapore, 217562, Singapore
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Fox Chase Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Gachon University Gil Medical Center
RECRUITINGIncheon, 21565, South Korea
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GenesisCare North Shore Health Hub
RECRUITINGSt Leonards, New South Wales, 2065, Australia
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Henry Dunant Hospital Center
RECRUITINGAthens, 115 26, Greece
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Hospital Clinic de Barcelona
RECRUITINGBarcelona, 08036, Spain
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Hospital Kuala Lumpur
RECRUITINGKuala Lumpur, WP Kuala Lumpur, 50586, Malaysia
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Hospital QuironSalud Malaga
RECRUITINGMálaga, 29004, Spain
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Hospital Universitari Son Espases
RECRUITINGPalma, Balearic Islands, 07120, Spain
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Hospital Universitario Central de Asturias
RECRUITINGOviedo, 33011, Spain
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Hospital Universitario y Politecnico La Fe
RECRUITINGValencia, 46026, Spain
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Humanity and Health Clinical Trial Centre
RECRUITINGCentral, Hong Kong
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Hyogo Cancer Center
RECRUITINGAkashi-shi, Hyōgo, 673-8558, Japan
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Illinois Cancer Specialists
RECRUITINGArlington Heights, Illinois, 60005, United States
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Istituto Europeo di Oncologia (IEO)
RECRUITINGMilan, 20141, Italy
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Kaiser Permanente Medical Center
RECRUITINGVallejo, California, 94589, United States
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Kangbuk Samsung Hospital
RECRUITINGSeoul, 03181, South Korea
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Kansai Medical University Hospital
RECRUITINGHirakata-shi, Osaka, 573-1191, Japan
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Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITINGKaohsiung City, 807, Taiwan
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Kurume University Hospital
RECRUITINGKurume-Shi, Fukuoka, 830-0011, Japan
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Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Miyagi Cancer Center
RECRUITINGNatori-shi, Miyagi, 981-1293, Japan
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National Cancer Center Hospital
RECRUITINGChuo-ku, Tokyo, 104-0045, Japan
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National Cancer Centre Singapore
RECRUITINGSingapore, 168583, Singapore
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National Hospital Organization Hokkaido Cancer Center
RECRUITINGSapporo, Hokkaido, 003-0804, Japan
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Niigata Cancer Center Hospital
RECRUITINGNiigata, Niigata, 951-8566, Japan
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Nippon Medical School Hospital
RECRUITINGBunkyo-ku, Tokyo, 113-8603, Japan
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Queen Mary Hospital
RECRUITINGHong Kong, 000000, Hong Kong
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SOC Oncologia Medica e dei Tumori Immuno-correlati
RECRUITINGAviano, 33081, Italy
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Shenandoah Oncology, P.C.
RECRUITINGWinchester, Virginia, 22601, United States
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Sunnybrook Research Institute
RECRUITINGToronto, Ontario, M4N 3M5, Canada
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Taichung Veterans General Hospital
RECRUITINGTaichung, 407219, Taiwan
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Tan Tok Seng Hospital
RECRUITINGSingapore, 308433, Singapore
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Texas Oncology
RECRUITINGDallas, Texas, 75246, United States
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The Catholic University of Korea, St. Vincent's Hospital
RECRUITINGSuwon, Gyeonggi-do, 16247, South Korea
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The Christie NHS Foundation Trust
RECRUITINGManchester, England, M20 4BX, United Kingdom
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The Ottawa Hospital Cancer Centre
RECRUITINGOttawa, Ontario, K1H 8L6, Canada
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The Royal Marsden NHS Foundation Trust
RECRUITINGLondon, SW3 6JJ, United Kingdom
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Thoracic General Hospital of Athens I Sotiria
RECRUITINGThessaloniki, 570 01, Greece
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Tokyo Metropolitan Komagome Hospital
RECRUITINGBunkyō-Ku, Tokyo, 113-8677, Japan
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UCSF Medical Center-Mission Bay
RECRUITINGSan Francisco, California, 94158, United States
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USC/Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University College London Hospitals NHS Foundation Trust
RECRUITINGLondon, England, NW1 2PG, United Kingdom
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Illinois Hospital and Health Sciences Systems
RECRUITINGChicago, Illinois, 60612, United States
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University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
Conditions
Explore the condition pages connected to this study.