Lung cancer Patients' own immune cells could shrink tumors in new trial

NCT ID NCT04614103

Recruiting now Disease control Sponsor: Iovance Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests a personalized therapy called LN-145, made from a patient's own tumor-fighting immune cells. Researchers take a sample of the tumor, grow the immune cells in a lab, and then infuse them back into the patient after a short course of chemotherapy. The goal is to see if this approach can shrink tumors in people with metastatic non-small-cell lung cancer who have not responded to standard treatments. The study plans to enroll 170 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

LN-145 (tumor infiltrating lymphocytes)

What this could lead to

If successful, this could offer a new treatment option for people with metastatic non-small-cell lung cancer who have not responded to other therapies.

What could go wrong

This is an early-phase trial with only 170 participants, so results may not apply to everyone. The treatment involves intensive chemotherapy and carries risks like infection and immune reactions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bronchial neoplasm carcinoma lung disorder lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC NON SMALL CELL LUNG CANCER

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Advocate Aurora Health
RECRUITING

Park Ridge, Illinois, 60068, United States
Allegheny General Hospital
RECRUITING

Natrona Heights, Pennsylvania, 15065, United States
Avera Medical Group Cancer Institute
ACTIVE_NOT_RECRUITING

Sioux Falls, South Dakota, 57105, United States
Azienda Ospedaliera Ospedali Riuniti Marche Nord
RECRUITING

Pesaro, 61122, Italy
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Banner Health MD Anderson
RECRUITING

Gilbert, Arizona, 85234, United States
Baptist Cancer Center
RECRUITING

Memphis, Tennessee, 38120, United States
C.H. Regional Reina Sofia
RECRUITING

Córdoba, 14004, Spain
CHRU de Poitiers La Miletrie
RECRUITING

Poitiers, 90577, France
CHU Nantes
RECRUITING

Nantes, 44093, France
CHU Nice
RECRUITING

Nice, 06001, France
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France
Centre Hospitalier Universitaire Vaudois Lausanne
RECRUITING

Lausanne, Canton of Vaud, 1011, Switzerland
Centre Hospitalier de l'Universite de Montreal (CHUM)
RECRUITING

Montreal, QC H2X 3E4, Canada
Charite- Universitätsklinikum Berlin
RECRUITING

Berlin, 13353, Germany
Clinical Universitaria de Navarra
RECRUITING

Pamplona, 31008, Spain
Consorcio Hospital General Universitario de Valencia
RECRUITING

Valencia, 46014, Spain
Fondazione IRCCS Policlinico San Matteo di Pavia
RECRUITING

Pavia, 27100, Italy
Gachon Unversity Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Gustave Roussy Cancer Campus
RECRUITING

Villejuif, 94805, France
Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
H Lee Moffitt Cancer Center and Research Institute
RECRUITING

Tampa, Florida, 33612, United States
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis
RECRUITING

Amsterdam, 1066, Netherlands
Hollywood Private Hospital Ramsay
RECRUITING

Nedlands, Western Australia, 6009, Australia
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29016, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario A Coruña
RECRUITING

A Coruña, 15006, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Madrid Sanchinarro - Centro Integral Oncologico Clara Campal
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Salamanca
RECRUITING

Salamanca, 90577, Spain
IRCCS Fondazione del Piemonte per l'Oncologia
RECRUITING

Piemonte, 10060, Italy
Institut Paoli Calmettes
RECRUITING

Marseille, 13009, France
Instituto Oncologico Rosell
RECRUITING

Barcelona, 08028, Spain
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
MD Anderson Cooper
RECRUITING

Camden, New Jersey, 08103, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
New York University Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Novant Health - Winston-Salem
ACTIVE_NOT_RECRUITING

Winston-Salem, North Carolina, 27103, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, B15 2GW, United Kingdom
Royal Marsden Hospital
RECRUITING

Chelsea, England, SW36JJ, United Kingdom
Rush University Medical Center
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60612, United States
Samsung Medical Center
RECRUITING

Seoul, Gangnam-gu, 6351, South Korea
Sanford Cancer Center
RECRUITING

Sioux Falls, South Dakota, 57102, United States
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58102, United States
Sarah Cannon Research Institute
RECRUITING

London, England, W1G 6AD, United Kingdom
Seattle Cancer Care Alliance
RECRUITING

Seattle, Washington, 98109, United States
Severance Hospital, Yonsei University
RECRUITING

Seoul, 3722, South Korea
St. Vincent's Hospital
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Sylvester Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Miami, Florida, 33136, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, England, M10 4BX, United Kingdom
University College London
RECRUITING

London, England, WC1E 68T, United Kingdom
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Illinois Hospital & Health Sciences System
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60612, United States
University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21201, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States
Universitätsklinikum Carl Gustav Carus, MK I
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Frankfurt
RECRUITING

Frankfurt, 60591, Germany
Universitätsklinikum Mannheim
RECRUITING

Mannheim, 68167, Germany
VCU Medical Center (Virginia Commonwealth University)
RECRUITING

Richmond, Virginia, 23298, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia