Cat allergy treatment gets a needle upgrade: fewer shots, same hope
NCT ID NCT06960382
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new method for treating cat allergies called intralymphatic immunotherapy (ILIT), where allergen extracts are injected directly into a lymph node. Thirty-six adults with cat-triggered allergic rhinitis and asthma will receive 3-4 ultrasound-guided injections. The goal is to see if this approach is safe and well-tolerated compared to standard allergy shots.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ALUTARD SQ Felis domesticus (cat hair allergen extract)
- What this could lead to
- If successful, this could lead to a faster, safer way to treat cat allergies with fewer injections than current methods.
- What could go wrong
- This is an early-phase trial with only 36 participants, so results may not apply to everyone. There is a risk of allergic reactions, including anaphylaxis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Informed consent as documented by signature. * Cat-dander-induced ARC as confirmed by patient history and type-1-sensitization to cat dander in skin and/or serum. Exclusion Criteria: * Hypersensitivity to phenol. * Planned depot steroid injection for treatment of ARC * Patients with uncontrolled asthma or FEV1 \< 70% of the predicted value in adults (after adequate pharmacological therapy). * Patients with a severe asthma exacerbation in the past 3 months. * Irreversible secondary changes in the affected organ (e.g., emphysema, bronchiectasis). * Chronic obstructive or restrictive lung disease. * Patients with active systemic autoimmune diseases and patients with immune deficiencies or immune weaknesses. * Severe chronic inflammatory diseases. * Concomitant infection with fever or other signs/symptoms of an acute or chronic infection at treatment visit. * Chronic obstructive or restrictive lung disease * Patients with malignant tumours that currently have clinical significance. * Disease or conditions rendering the treatment of anaphylactic reactions difficult (symptomatic coronary heart diseases, severe arterial hypertension, and treatment with beta-blockers). * Known cardiovascular disease, i.e., not even NYHA class I. * Use of ACE-blockers. * Recent or on-going hepatic or renal disease. * Severe chronic renal insufficiency (due to aluminium burden). * Alcohol or drug abuse * Women who are pregnant and breast feeding * Women of childbearing age who wish to become pregnant or do not use contraception. * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Participation in another study with investigational drug within the 30 days preceding and during the present study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Hospital Zurich
RECRUITINGZurich, 8091, Switzerland
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