Breakthrough asthma drug may let patients ditch puffers

NCT ID NCT07363642

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing whether people with severe asthma who take the drug Tezepelumab can safely cut back on their other daily asthma medications without losing control of their symptoms. About 400 participants aged 12 to 80 will be enrolled. The goal is to see if they can reduce or stop certain maintenance drugs while staying well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tezepelumab
What this could lead to: If successful, this could show that many severe asthma patients can safely reduce their daily controller medications while maintaining good symptom control.
What could go wrong: This is a single-arm study without a placebo group, so results may be less definitive. Reducing medication could lead to worsening asthma in some patients, and benefits may not apply to all types of severe asthma.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ASTHMA

Contacts and locations

Locations

Research Site
RECRUITING

Beijing, 100020, China
Research Site
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Beijing, 100191, China
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Beijing, 100730, China
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NOT_YET_RECRUITING

Beijing, 100730, China
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NOT_YET_RECRUITING

Beijing, 102300, China
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NOT_YET_RECRUITING

Beijing, 10730, China
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NOT_YET_RECRUITING

Beijing, 211405, China
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NOT_YET_RECRUITING

Binzhou, 256606, China
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NOT_YET_RECRUITING

Changsha, 410008, China
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Changsha, 430033, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chengdu, 610095, China
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Chengdu, 610500, China
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Chongqing, 400042, China
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Chongqing, 400072, China
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NOT_YET_RECRUITING

Deyang, 618000, China
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Fuzhou, 350001, China
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NOT_YET_RECRUITING

Guangzhou, 510080, China
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NOT_YET_RECRUITING

Guangzhou, 510100, China
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Guangzhou, 510163, China
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NOT_YET_RECRUITING

Guangzhou, 510180, China
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Guangzhou, 510280, China
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Guangzhou, 510515, China
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Guangzhou, 510620, China
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NOT_YET_RECRUITING

Guiyang, 510630, China
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Hangzhou, 310003, China
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Hangzhou, 310006, China
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Hangzhou, 310016, China
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Hefei, 230061, China
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Hefei, 230601, China
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NOT_YET_RECRUITING

Hohhot, 010017, China
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Jiangmen, 529000, China
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NOT_YET_RECRUITING

Jinan, 250012, China
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NOT_YET_RECRUITING

Jinan, 250014, China
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NOT_YET_RECRUITING

Jinan, 250021, China
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NOT_YET_RECRUITING

Jining, 272006, China
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NOT_YET_RECRUITING

Kunming, 650032, China
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Leshan, 614000, China
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NOT_YET_RECRUITING

Linyi, CN-276003, China
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Luzhou, 646000, China
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NOT_YET_RECRUITING

Meizhou, 514700, China
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Mianyang, 621000, China
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Nanchang, 330006, China
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Nanjing, 210029, China
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NOT_YET_RECRUITING

Nanjing, 211100, China
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NOT_YET_RECRUITING

Nanning, 530000, China
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RECRUITING

Ningbo, 315010, China
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NOT_YET_RECRUITING

Quanzhou, 362000, China
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NOT_YET_RECRUITING

Shanghai, 200000, China
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NOT_YET_RECRUITING

Shanghai, 200003, China
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NOT_YET_RECRUITING

Shanghai, 200025, China
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NOT_YET_RECRUITING

Shanghai, 200032, China
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NOT_YET_RECRUITING

Shanghai, 200433, China
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Shanghai, 310000, China
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Shantou, 515041, China
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WITHDRAWN

Shenyang, 110001, China
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NOT_YET_RECRUITING

Shenzhen, 518020, China
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NOT_YET_RECRUITING

Shenzhen, 518036, China
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Shijiazhuang, 054001, China
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Suining Shi, 629000, China
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Suzhou, 215006, China
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NOT_YET_RECRUITING

Taiyuan, 030001, China
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NOT_YET_RECRUITING

Taiyuan, 030032, China
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Tianjin, 300192, China
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NOT_YET_RECRUITING

Weifang, 261000, China
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Wenzhou, 325027, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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NOT_YET_RECRUITING

Wuxi, 214023, China
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Xi'an, 710061, China
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Zhangzhou, 363099, China
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NOT_YET_RECRUITING

Zhanjiang, 524004, China
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NOT_YET_RECRUITING

Zhengzhou, 450003, China
Research Site
RECRUITING

Zhengzhou, 450007, China
Research Site
NOT_YET_RECRUITING

Zhongshan, 528403, China

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