New asthma drug could cut attacks with just two shots a year

NCT ID NCT07276724

Recruiting now Disease control Sponsor: Generate Biomedicines Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 4 times

Summary

This phase 3 trial tests whether GB-0895, given every 6 months, can reduce asthma attacks in adults and teens (ages 12–80) with severe asthma that isn't controlled by standard inhalers. About 786 participants will receive either GB-0895 or a placebo, and researchers will track how many asthma attacks occur over 52 weeks. The goal is to see if this treatment can help people breathe easier and need fewer emergency treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GB-0895
What this could lead to: If it works, this could provide a new treatment option that reduces asthma attacks with dosing only every 6 months, improving control for people with severe asthma.
What could go wrong: This is still an experimental drug, and results may not show a significant benefit over placebo. Side effects or lack of efficacy could limit its use.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ASTHMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Research Site 01
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Miami Lakes, Florida, 33014, United States

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Research Site 02
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Tampa, Florida, 33613, United States

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Research Site 03
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Hialeah, Florida, 33016, United States

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Research Site 04
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Miami, Florida, 33126, United States

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Research Site 05
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Lewisville, Texas, 75057, United States

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Research Site 06
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Flint, Michigan, 48504, United States

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Research Site 07
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Dallas, Texas, 75230, United States

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Research Site 08
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North Miami, Florida, 33169, United States

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Research Site 09
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Houston, Texas, 77099, United States

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Research Site 10
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Palm Springs, Florida, 33461, United States

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Research Site 11
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Houston, Texas, 77084, United States

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Research Site 12
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Doral, Florida, 33122, United States

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Research Site 13
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West Hills, California, 91307, United States

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Research Site 14
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Gainesville, Florida, 32607, United States

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Research Site 15
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Colorado Springs, Colorado, 80923, United States

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Research Site 16
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Baltimore, Maryland, 21237, United States

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Research Site 17
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Dallas, Texas, 75254, United States

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Research Site 18
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Rincon, Georgia, 31326, United States

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Research Site 19
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Baytown, Texas, 77521, United States

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Research Site 20
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Towson, Maryland, 21204, United States

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Research Site 21
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Riverton, Utah, 84096, United States

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Research Site 22
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Kerrville, Texas, 78028, United States

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Research Site 23
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Northridge, California, 91324, United States

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Research Site 24
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Amarillo, Texas, 79106, United States

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Research Site 25
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Kendall, Florida, 33176, United States

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Research Site 26
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Pasadena, California, 91105, United States

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Research Site 27
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Gastonia, North Carolina, 28054, United States

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Research Site 28
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Columbia, Maryland, 21045, United States

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Research Site 29
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Rancho Cucamonga, California, 91730, United States

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Research Site 30
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Olive Branch, Mississippi, 38654, United States

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Research Site 31
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Glenview, Illinois, 60026, United States

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Research Site 32
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Brooksville, Florida, 34613, United States

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Research Site 33
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McKinney, Texas, 75069, United States

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Research Site 34
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Valencia, California, 91355, United States

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Research Site 35
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Bucharest, Bucharest, 061692, Romania

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Research Site 36
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Frankfurt am Main, Hesse, 60596, Germany

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Research Site 37
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The Bronx, New York, 10461, United States

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Research Site 38
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Kozloduy, Vratsa, 3320, Bulgaria

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Research Site 39
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Vidin, 3703, Bulgaria

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Research Site 40
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Berlin, 10119, Germany

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Research Site 41
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Oradea, Bihor County, 410163, Romania

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Research Site 42
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Deggingen, Baden-Wurttemberg, 73326, Germany

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Research Site 43
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Lübeck, Germany

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Research Site 44
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Berlin, State of Berlin, 10717, Germany

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Research Site 45
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Budapest, 1047, Hungary

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Research Site 46
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Szombathely, 9700, Hungary

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Research Site 47
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Mosonmagyaróvár, 9200, Hungary

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Research Site 48
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Figueira da Foz Municipality, Figueira da Foz, 3094-001, Portugal

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Research Site 49
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Berlin, State of Berlin, 13187, Germany

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Research Site 50
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Brasov, 500051, Romania

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Research Site 51
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Craiova, Dolj, 200678, Romania

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Research Site 52
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Riga, Latvia

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Research Site 53
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Szigetvár, 7900, Hungary

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Research Site 54
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Pleven, Bulgaria

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Research Site 55
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Plovdiv, Bulgaria

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Research Site 56
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Haskovo, 6300, Bulgaria

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Research Site 57
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Sydenham, KwaZulu-Natal, 4091, South Africa

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Research Site 58
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Durban, KwaZulu-Natal, 4092, South Africa

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Research Site 59
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Johannesburg, Gauteng, 2001, South Africa

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Research Site 60
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KwaDukuza, Gauteng, 4449, South Africa

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Research Site 61
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Welkom, Free State, 9460, South Africa

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Research Site 62
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Heerlen, Limburg, 6419PC, Netherlands

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Research Site 63
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Sofia, Sofia, 1756, Bulgaria

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Research Site 64
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Cluj-Napoca, Cluj, 400371, Romania

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Research Site 65
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Sofia, Sofia, 1407, Bulgaria

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Research Site 66
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Cluj-Napoca, Cluj, 400332, Romania

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Research Site 68
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Cape Town, Western Cape, 7530, South Africa

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