New contrast mammography could spot breast cancer recurrence earlier

NCT ID NCT06105749

Recruiting now Diagnosis Sponsor: Wendie Berg Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is testing whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find new breast cancers in women who have already had breast cancer. The goal is to see if CEM detects more cancers while keeping false alarms low. About 1,500 women aged 30-79 who are at least one year past their breast cancer treatment will participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: contrast-enhanced mammography (CEM)
What this could lead to: If successful, this could lead to a more accurate screening method for women who have had breast cancer, catching new cancers earlier with fewer false alarms.
What could go wrong: This is a single-arm study without a control group, so results may not prove superiority over standard screening. Also, CEM requires an IV contrast injection, which carries a small risk of allergic reaction.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm female breast carcinoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CANCER FEMALE BREAST NEOPLASMS NEOPLASMS

Contacts and locations

Locations

Hillman Cancer Center at Shadyside
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Magee Womancare Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Magee-Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC Magee at the Lemieux Sports Complex
RECRUITING

Cranberry Township, Pennsylvania, 16066, United States
UPMC Magee-Womens Imaging - Bethel Park
RECRUITING

Bethel Park, Pennsylvania, 15102, United States
UPMC West Mifflin Outpatient Center
RECRUITING

West Mifflin, Pennsylvania, 15236, United States

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