Proton beams may ease brain tumor treatment side effects

NCT ID NCT04752280

First seen Mar 13, 2026 · Last updated Jun 23, 2026 · Updated 14 times

Summary

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, an aggressive brain cancer. About 326 patients will receive either proton or photon therapy alongside standard care. The main goal is to see if proton therapy reduces early toxicities within the first four months, while also tracking survival and quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Klinikum Stuttgart

    NOT_YET_RECRUITING

    Stuttgart, Germany

    Contact

  • Universitätsklinikum Gießen und Marburg

    NOT_YET_RECRUITING

    Marburg, Germany

    Contact

  • Universitätsklinikum Heidelberg

    RECRUITING

    Heidelberg, Germany

    Contact

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Proton beam radiation

What this could lead to

If successful, this could show that proton therapy causes fewer short-term side effects than standard photon radiation for glioblastoma patients.

What could go wrong

This trial focuses on reducing side effects, not on curing the disease. The overall prognosis for glioblastoma remains poor, and the benefit may be limited to early toxicity reduction.

Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.