Massive brain cancer trial aims to find better treatments

NCT ID NCT03970447

Recruiting now Disease control Sponsor: Global Coalition for Adaptive Research Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 6 times

Summary

This large international trial is testing several different drugs, including temozolomide, lomustine, regorafenib, and paxalisib, in people with newly diagnosed or recurrent glioblastoma, an aggressive brain cancer. The study uses an adaptive design, meaning it can quickly drop ineffective treatments and focus on promising ones. The main goal is to see if these drugs help patients live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Temozolomide, Lomustine, Regorafenib, Paxalisib, and radiation therapy
What this could lead to: If successful, this trial could identify more effective drug combinations for glioblastoma, potentially extending survival and improving quality of life for patients.
What could go wrong: This is an early-phase adaptive trial testing multiple drugs, so many may not prove effective. Glioblastoma is a very aggressive cancer, and even promising treatments often fail in larger studies.

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Conditions

The condition(s) this trial relates to.

glioblastoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

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Locations

Allegheny General Hospital
COMPLETED

Pittsburgh, Pennsylvania, 15212, United States
Allina Health Systems/Abbott Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States

Contact Email: •••••@•••••
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Cedars Sinai - Samuel Oschin Comprehensive Cancer Institute
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Centre Hospitalier Lyon Sud / Hôpital Neurologique P. Wertheimer
RECRUITING

Bron, 69677, France
Centre Hospitalier Universitaire Vaudois Lausanne
RECRUITING

Lausanne, Canton of Vaud, 1011, Switzerland
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Comprehensive Cancer Center of Wake Forest*
RECRUITING

Winston-Salem, North Carolina, 272157, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Dr. Senckenbergisches Institut für Neuroonkologie
RECRUITING

Frankfurt, 60528, Germany
Duke University Medical Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Froedtert Hospital/Medical College of Wisconsin
ACTIVE_NOT_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Henry Ford Health System
COMPLETED

Detroit, Michigan, 48202, United States
Hopital Piti-Salpetriere
RECRUITING

Paris, 75013, France
Hopital de la Timone
RECRUITING

Marseille, 13005, France
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
LSU Health Sciences Center - New Orleans
COMPLETED

New Orleans, Louisiana, 70112, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Cancer Center
COMPLETED

Jacksonville, Florida, 32224, United States
Mayo Clinic Cancer Center - Rochester
COMPLETED

Rochester, Minnesota, 55905, United States
Medical University of South Carolina - Hollings Cancer Center
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Cancer Center*
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Montreal Neurological Institute and Hospital, McGill University
RECRUITING

Montreal, Quebec, H3A 2B4, Canada
Northern Sydney Cancer Centre/Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, 2065, Australia
Ohio State University Cancer Center
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
Perlmutter Cancer Center, NYU Langone Health
ACTIVE_NOT_RECRUITING

New York, New York, 10016, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, Australia
Piedmont Atlanta Hospital
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30309, United States
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C1, Canada
Royal Brisbane and Women's Hospital
RECRUITING

Herston, Queensland, 4029, Australia
St. Joseph Hospital
RECRUITING

Orange, California, 92868, United States
Stanford Cancer Center
COMPLETED

Stanford, California, 94305, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Sylvester Comprehensive Cancer Center*
RECRUITING

Miami, Florida, 33136, United States
Texas Oncology - Austin
ACTIVE_NOT_RECRUITING

Austin, Texas, 78705, United States
Uniklinik Koeln - Zentrum fuer Neurologie und Psychiatrie
ACTIVE_NOT_RECRUITING

Cologne, 50937, Germany
Universitaetsklinikum Heidelberg - Neurologische Klinik
RECRUITING

Mannheim, 68167, Germany
University Hospital Zurich
RECRUITING

Zurich, Switzerland
University Hospitals Cleveland Medical Center*
RECRUITING

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35249, United States
University of California, Los Angeles
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90095, United States
University of California, San Diego
RECRUITING

La Jolla, California, 92093, United States
University of California, San Francisco
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
University of Colorado Denver
RECRUITING

Aurora, Colorado, 80045, United States
University of Mississippi Medical Center
COMPLETED

Jackson, Mississippi, 39213, United States
University of Pennsylvania - Perelman Center for Advanced Medicine
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center - Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Texas - MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Utah - Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
University of Virginia Health
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Washington Medical Center
ACTIVE_NOT_RECRUITING

Seattle, Washington, 98101, United States
Universitätsklinik Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Université de Sherbrooke
ACTIVE_NOT_RECRUITING

Sherbrooke, Quebec, J1H 5H3, Canada
Washington University School of Medicine - Siteman Cancer Center
COMPLETED

St Louis, Missouri, 63110, United States
Winship Cancer Institute of Emory University
COMPLETED

Atlanta, Georgia, 30322, United States
Yale Cancer Center / Smilow Cancer Hospital*
RECRUITING

New Haven, Connecticut, 06511, United States

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