Brain tumor surgery at recurrence: does it help?

NCT ID NCT02394626

Recruiting now Knowledge-focused Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether surgery can help people whose glioblastoma has come back after initial treatment. 120 participants will be randomly assigned to either have surgery followed by second-line therapy, or to have second-line therapy alone. The goal is to see if surgery improves overall survival, neurological function, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgery (craniotomy and tumor resection)
What this could lead to: If successful, this trial could provide the first strong evidence that surgery for recurrent glioblastoma extends survival, potentially changing standard care.
What could go wrong: This is a phase 2 trial with only 120 participants, so results are preliminary. Past retrospective studies have been mixed, and surgery carries risks like infection or neurological damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

Locations

Assistance Publique - Hôpitaux de Marseille, Department of Neuro-Oncology
RECRUITING

Marseille, France
Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Neurosurgery
RECRUITING

Paris, France
Centre Hospitalier Régional et Universitaire de Tours (CHRU Tours), Department of Neurosurgery
RECRUITING

Tours, France
Centre Hospitalier Universitaire Dijon Bourgogne, Department of Neurosurgery
RECRUITING

Dijon, France
Centre Hospitalier Universitaire de Nice, Department of Neurosurgery
RECRUITING

Nice, France
Centre Hospitalier Universitaire de Saint-Étienne, Department of Neurosurgery
RECRUITING

Saint-Etienne, France
Dep. of Neurosurgery, Bern University Hospital
RECRUITING

Bern, 3010, Switzerland
Dep. of Neurosurgery, Centre hospitalier universitaire vaudois
RECRUITING

Lausanne, 1011, Switzerland
Department of Neurosurgery, Amsterdam University Medical Center
RECRUITING

Amsterdam, Netherlands
Department of Neurosurgery, Centro Hospitalar Universitário Lisboa Norte - Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
Department of Neurosurgery, Haaglanden Medical Center, The Hague
RECRUITING

The Hague, Netherlands
Department of Neurosurgery, Hospital of Larissa & General Hospital of Larissa
RECRUITING

Larissa, 412 21, Greece
Department of Neurosurgery, L'Hospitalet de Llobregat, Barcelona
RECRUITING

Barcelona, Spain
Department of Neurosurgery, Radboud University Medical Center, Nijmegen
RECRUITING

Nijmegen, Netherlands
Helios Klinikum Erfurt
RECRUITING

Erfurt, 99089, Germany
Hospices Civils de Lyon - CHU de Lyon, Department of Neuro-Oncology
RECRUITING

Lyon, France
Institut de Cancérologie Strasbourg Europe (ICANS), Department of Oncology
RECRUITING

Strasbourg, France
Johannes Kepler University Linz University, Clinic for Neurosurgery
RECRUITING

Linz, Austria
Medical University of Vienna, Department of Neurosurgery
RECRUITING

Vienna, Austria
Ospedale Regionale di Lugano
RECRUITING

Lugano, 6900, Switzerland
University Hospital of Umeå, Department of Diagnostics and Intervention
NOT_YET_RECRUITING

Umeå, Sweden
University of Gothenburg, Department of Clinical Neuroscience
NOT_YET_RECRUITING

Gothenburg, Sweden
Universitätsklinikum Innsbruck
RECRUITING

Innsbruck, Austria
Universitätsklinikum Münster
RECRUITING

Münster, 48149, Germany
Universitätsspital Basel
RECRUITING

Basel, 4031, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.