Brain cancer hope: new drugs tested in major trial

NCT ID NCT02977780

Recruiting now Disease control Sponsor: Patrick Wen, MD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial is testing several experimental drugs, alone or in combination, for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 460 participants will receive one of the study drugs or standard therapy. The main goal is to see if these new treatments help people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Temozolomide, Neratinib, QBS10072S, Abemaciclib, CC-115
What this could lead to: If successful, this trial could identify new drug combinations that extend survival for people with glioblastoma, a hard-to-treat brain cancer.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The drugs may not work better than standard care, and side effects could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma gliosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

Locations

Cleveland Clinic
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Huntsman Cancer Institute
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Lifespan / Rhode Island Hospital
ACTIVE_NOT_RECRUITING

Providence, Rhode Island, 02903, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
UT MD Anderson Cancer Center
COMPLETED

Houston, Texas, 77030, United States
University of Alabama at Birmingham
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35294, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Virginia Health System
COMPLETED

Charlottesville, Virginia, 22908, United States

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