Triple drug cocktail takes on recurrent glioblastoma

NCT ID NCT07263438

Recruiting now Disease control Sponsor: Centre Hospitalier Universitaire Vaudois Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests a combination of three drugs—trimipramine (an antidepressant), atezolizumab (an immunotherapy), and bevacizumab (a drug that cuts off blood supply to tumors)—in 59 patients whose glioblastoma has returned after standard treatment. The goal is to see if the combo can slow tumor growth and to measure how much trimipramine reaches the tumor. Patients receive treatment for up to 2 years, with follow-up for safety and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trimipramine, atezolizumab, and bevacizumab
What this could lead to: If successful, this combination could offer a new treatment option to slow or stop the growth of recurrent glioblastoma, a brain cancer with few effective therapies.
What could go wrong: This is an early phase II trial with only 59 patients, so results may not apply to everyone. The drugs can cause serious side effects like bleeding, high blood pressure, or immune reactions.

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Conditions

The condition(s) this trial relates to.

glioblastoma Recurrence secondary neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA RECURRENCE TUMOR

Contacts and locations

Locations

Bern Inselspital
RECRUITING

Bern, Canton of Bern, 3010, Switzerland
Centre Hospitalier Universitaire Vaudois
RECRUITING

Lausanne, Canton of Vaud, 1011, Switzerland
HFR Fribourg - Hôpital cantonal
RECRUITING

Fribourg, Canton of Fribourg, 1708, Switzerland
Kantonsspital Aarau
RECRUITING

Aarau, Canton of Aargau, 5001, Switzerland
Luzerner Kantonsspital
RECRUITING

Lucerne, Canton of Lucerne, 6000, Switzerland
Universitätsspital Basel
RECRUITING

Basel, Basel, 4031, Switzerland
Universitätsspital Zürich
RECRUITING

Zurich, Canton of Zurich, 8091, Switzerland

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