GLIOBLASTOMA

This study tested whether giving chemotherapy and radiation before surgery could better control aggressive brain tumors called glioblastoma. The approach aimed to delay tumor regrowth compared to standard treatment. The trial was terminated early with only 2 participants enrolled…

This was an early safety study of a new oral drug called TAS2940 for people with advanced solid tumors that have specific genetic changes (EGFR or HER2). The main goals were to find a safe dose and see how the body processes the drug. The trial was terminated and enrolled 29 part…

This early-stage study tested a new oral drug called navtemadlin (AMG 232) for glioblastoma, a fast-growing brain cancer. The trial had two parts: first, to see if the drug could reach brain tumor tissue in patients whose cancer had returned; second, to find a safe dose to combin…

This study tested an experimental drug called VAL-083 for adults with glioblastoma, a fast-growing brain cancer that had returned after standard treatments failed. It compared VAL-083 against a doctor's choice of other approved chemotherapy drugs to see which helped patients live…

This study tested whether the drug pemigatinib could help control recurrent brain tumors that have specific genetic changes in the FGFR genes. The trial included about 83 adults with glioblastoma or other brain tumors that had returned after previous treatments. Participants took…

This study tested if adding an experimental drug called Zotiraciclib to a standard chemotherapy (temozolomide) could better control aggressive brain tumors that have returned after initial treatment. The trial had two parts: first to find a safe dose, then to compare how long the…

This study tested if a special type of MRI scan using an iron-based dye (ferumoxytol) could help doctors better understand brain tumor scans. It focused on patients with a severe brain cancer (glioblastoma) who were receiving a standard immunotherapy drug (pembrolizumab) along wi…

This study tested whether a hemp-derived CBD product could help reduce anxiety and improve quality of life in people newly diagnosed with glioblastoma, an aggressive brain cancer. The trial was designed as an 8-week study comparing the CBD product to a placebo in patients receivi…

This study tested whether a drug called solriamfetol, which promotes wakefulness, could help adults with stable brain tumors (gliomas) feel less sleepy and fatigued, and improve their memory and quality of life. The main goal was to check the drug's safety at different doses. The…

This study aimed to understand if measuring levels of a tiny molecule called microRNA-10b in brain tumor samples could help doctors predict patient survival and better classify different types of brain cancer. Researchers collected tumor, blood, and spinal fluid samples from 94 a…

This early study aimed to see if an oral drug called infigratinib could reach brain tumors in patients with a specific genetic change. A small group of adults with recurrent high-grade glioma took the drug before their scheduled tumor removal surgery. Researchers then measured ho…

This very early study aimed to see if ketoconazole, a drug used for fungal infections, could get into brain tumors at high enough levels to potentially stop cancer cell growth. Researchers planned to measure drug levels directly in the tumor tissue of a small number of adults wit…

This small, early-stage study tested whether a common antifungal drug called posaconazole can get into brain tumors at high enough levels to potentially stop cancer cells from growing. Researchers gave the drug to a few adults with a type of aggressive brain cancer before their s…