GLIOBLASTOMA

This early-stage study tested a new drug called RMC-5552 in 7 adults whose glioblastoma (a type of brain cancer) had returned after standard treatment. The drug works by blocking a protein that helps cancer cells grow. The main goals were to find the safest dose and see if the dr…

This study aimed to see if giving chemotherapy and radiation before surgery could help people with a fast-growing brain cancer called glioblastoma. Only 2 people took part before the study was stopped early. The main goals were to check safety and whether the treatment delayed th…

This early-stage trial tested the drug navtemadlin in 32 adults with glioblastoma, an aggressive brain cancer. The goal was to find the safest dose and see how much drug reaches the tumor. The study was stopped early, but results may guide future treatments.

This study tested a drug called pemigatinib in adults whose brain tumors (glioblastoma or other gliomas) had come back after previous treatment and had specific FGFR gene changes. The goal was to see if the drug could shrink tumors. Participants took pemigatinib pills daily for t…

This study tested a new drug called VAL-083 in people with glioblastoma, an aggressive brain cancer, that had come back after standard treatments. The goal was to see if VAL-083 could help patients live longer. However, the trial was stopped early after only 2 people enrolled, so…

This study tested a new way to deliver radiation for glioblastoma, a fast-growing brain tumor. It compared standard 3D radiation to a more precise method guided by special MRI scans. The goal was to see if the newer approach could help patients live longer. The trial included 180…

This early-stage study tested a new drug called TAS2940 in 29 people with advanced solid tumors (like lung, breast, or brain cancer) that had certain genetic changes (EGFR or HER2). The goal was to find a safe dose and see if it could shrink tumors. The trial was stopped early, s…

This study tested an experimental drug called zotiraciclib (TG02) combined with the standard chemotherapy temozolomide in adults with recurrent anaplastic astrocytoma or glioblastoma. The goal was to find safe doses and see if the combination works better than temozolomide alone.…

This study tested whether a special MRI using ferumoxytol (an iron-based dye) can help doctors tell if a brain tumor (glioblastoma) is truly shrinking from immunotherapy or just showing temporary swelling from treatment. About 52 patients were planned, but the study was stopped e…

This study tested a drug called solriamfetol to see if it could help people with brain tumors (gliomas) feel more awake and improve their memory, mood, and quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for side effects.

This study aimed to see if a high-CBD hemp product could reduce anxiety and improve quality of life in people newly diagnosed with glioblastoma, a serious brain tumor. Only 2 participants were enrolled before the study was stopped early. The approach involved comparing the CBD pr…

This early-phase trial aimed to see how well the drug infigratinib reaches brain tumors in patients with recurrent high-grade glioma (a type of brain cancer) who were scheduled for surgery. Only 7 of the planned 20 participants were enrolled before the study was terminated. The m…

This early-phase study aimed to see if ketoconazole, a drug used for fungal infections, could enter glioblastoma brain tumors in high enough amounts to stop cancer cells from dividing. Only one person took part before the study was stopped early. The main goal was to measure drug…

This study looked at a small genetic molecule called microRNA-10b in brain tumor samples from 94 patients. Researchers wanted to see if higher levels of this molecule could help predict how long patients live or how their tumor behaves. They also tested in the lab whether blockin…

This early-stage study tested whether posaconazole, a drug normally used for fungal infections, can get into glioblastoma brain tumors at levels high enough to stop cancer cells from dividing. Only 7 people took part before the study was stopped early. The goal was to see if the …