GLIOBLASTOMA

This study is testing the safety of a new type of MRI scan that helps surgeons see the hard-to-spot edges of a deadly brain tumor called glioblastoma. The goal is to see if using this scan to guide surgery allows doctors to safely remove more of the tumor than standard methods. T…

This study is testing whether adding a new drug called ADI-PEG 20 to standard radiation and chemotherapy can help control aggressive brain tumors in children, teens, and young adults. The first part will find the safest dose, and the second part will see if the combination helps …

This trial is testing whether adding the antidepressant drug vortioxetine to standard brain cancer treatment helps patients live longer without their cancer worsening. The drug was identified through lab tests showing it might fight brain cancer cells. The study will enroll 78 ad…

This study is testing a new treatment order for aggressive brain tumors (high-grade gliomas). Researchers want to see if giving the chemotherapy drug temozolomide before radiation therapy is effective and safe. They believe this approach could make MRI scans after treatment easie…

This trial tests whether placing tiny, slow-release chemotherapy beads directly into the cavity left after brain tumor surgery helps control glioblastoma better than standard treatment alone. It involves 147 adults with newly diagnosed or recurrent tumors suitable for surgery. Th…

This study is testing whether adding a personalized vaccine to standard chemotherapy helps control glioblastoma, an aggressive brain cancer, after initial surgery and radiation. The vaccine is made from the patient's own immune cells and tumor proteins. Researchers will compare h…

This is a first-in-human safety study testing a personalized vaccine called Bvax for people newly diagnosed with glioblastoma, a fast-growing brain cancer. The vaccine is made from the patient's own blood cells and tumor tissue and is given alongside standard chemotherapy and rad…

This study is testing a personalized approach to find treatments for brain tumors that have stopped responding to standard therapies. Doctors will test tumor cells from surgery in a lab to see which drugs might work best for each patient. The goal is to see if this 'drug-matching…

This is a first-in-human study to find a safe dose of an experimental oral drug called GLIX1 for adults with aggressive brain tumors (high-grade glioma or glioblastoma) that have returned or worsened after standard treatments. The main goal is to check the drug's safety and side …

This early-stage study is testing two new drugs, CTX-009 and CTX-471, for people whose aggressive brain cancer (glioblastoma) has returned after standard treatment. Researchers want to see if using CTX-009 alone or combined with CTX-471 is safe and can help control the tumor and …

This study is testing a new AI-guided method for delivering radiation therapy to people with glioma, a type of brain tumor. The goal is to see if using artificial intelligence to adjust radiation doses based on frequent MRI and PET scans during treatment can better control the tu…

This is a small, early-stage study to see if a combination treatment is safe for people with a specific type of recurrent brain cancer (glioblastoma). Doctors will use a focused ultrasound device to target the tumor area along with an immunotherapy drug called pembrolizumab. The …

This study is testing whether using a special type of MRI scan during surgery helps doctors remove more of a deadly brain tumor called glioblastoma. The new scan aims to reveal hidden cancer cells that standard scans miss. Researchers will compare this new surgical approach to th…

This early study is testing a special fluorescent dye called panitumumab-IRDye800. It is given by IV before brain surgery to see if it makes tumors glow under a special camera, helping surgeons see the edges of the tumor more clearly. The main goals are to check if the dye is saf…

This study is testing whether a special type of brain scan (PET-MRI) can be done safely and effectively within two days after surgery for glioblastoma, a serious brain cancer. The goal is to see if this early scan can detect leftover tumor tissue better than the standard MRI scan…

This study aims to find the best way to close the skin after brain tumor surgery. Researchers will compare two common stitching techniques in 382 adult patients to see which leads to fewer wound problems like infections or leaks. The goal is to improve healing so patients can rec…

This study aims to understand how the amount of brain tumor removed during surgery affects patient survival when followed by standard chemotherapy and radiation. Researchers will observe 50 adults with glioblastoma who have already had surgery and standard follow-up treatment. Th…

This study aims to understand why glioblastoma, an aggressive brain cancer, almost always returns after treatment. Researchers will collect tumor tissue and blood samples from 45 patients undergoing surgery to analyze the cancer's biology. The goal is to discover new targets for …

This study aims to learn which surgical approaches work best for treating glioblastoma, a fast-growing brain tumor. Researchers will observe 100 adult patients from hospitals in Europe and the U.S., tracking their survival, recovery, and quality of life after different types of s…

This study aims to find out if using MRI scans, instead of or alongside standard CT scans, can help doctors plan and adjust radiotherapy for cancer more precisely. It will involve up to 165 people, including healthy volunteers and patients with cancers like brain, stomach, and pa…

This early research study aims to understand how Acetadote affects metabolism in glioblastoma brain tumors. Researchers will give Acetadote to 10 newly diagnosed patients before surgery, then analyze tumor tissue and MRI scans to see how the drug changes tumor chemistry. The goal…

This study aims to understand if patterns seen on a special type of brain scan (MRS) are connected to simple blood test results in people newly diagnosed with glioblastoma, an aggressive brain cancer. Researchers will enroll 30 patients to collect scan data and blood samples befo…