GLIOBLASTOMA

This study tests a new approach for people with brain tumors that have not responded to standard treatments. A lab test called pharmacoscopy analyzes a patient's tumor cells to find which drugs might work best for them. The goal is to see if this personalized method is feasible a…

This study tests whether adding an experimental drug (ADI-PEG 20) to standard radiation and chemotherapy can help children, teens, and young adults with newly diagnosed high-grade glioma. About 97 participants will receive the drug combination to see if it is safe and delays tumo…

This study tests a personalized vaccine (ZSNeo-DC1.1) made from a patient's own immune cells, combined with standard chemotherapy, for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 78 participants who have already had surgery and chemoradiation will …

This study tests whether vortioxetine, a drug currently used for depression, can help people with newly diagnosed glioblastoma, an aggressive brain cancer. Researchers identified vortioxetine by testing many drugs on tumor samples in the lab. The trial will enroll 78 adults who w…

This early-phase study tests whether combining focused ultrasound (sound waves) with the immunotherapy drug pembrolizumab is safe and feasible for people with a specific type of recurrent glioblastoma (a fast-growing brain cancer). Only 8 participants who have already had surgery…

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma has returned after standard treatment. The goal is to see if the drugs are safe and can help control the tumor and extend survival. About 54 adults with up to two recurrences will take part…

This study tests whether a special MRI technique (CEST) can help surgeons see and remove more glioblastoma tissue than standard surgery. About 60 adults with newly diagnosed glioblastoma will be randomly assigned to either CEST-guided surgery or standard surgery. The goal is to s…

This phase 2 trial tests whether placing tiny chemotherapy-releasing seeds (irinotecan-ChemoSeed) directly into the brain after removing a glioblastoma tumor can help keep the cancer from coming back. About 147 adults with newly diagnosed or recurrent glioblastoma will take part.…

This study tests giving chemotherapy before radiation for people with high-grade gliomas, a type of aggressive brain tumor. The goal is to see if this approach works well and makes MRI scans easier to read, since radiation can change how the brain looks. About 70 adults aged 18-8…

This early-phase trial tests a personalized vaccine called Bvax, made from a patient's own tumor, alongside standard chemoradiation for newly diagnosed glioblastoma. The study aims to see if the vaccine is safe and feasible in 25 participants. It is not a cure, but a way to poten…

This early-stage study tests a fluorescent dye called panitumumab-IRDye800 to see if it can help surgeons identify brain tumors during surgery. About 30 adults with brain lesions (like meningioma or glioblastoma) will receive the dye before their operation. The main goal is to ch…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how doct…

This study tests a new way to treat brain tumors (gliomas) by using MRI and PET scans during radiation therapy. An artificial intelligence system will help doctors adjust the radiation dose to target resistant areas and protect healthy tissue. The goal is to improve tumor control…

This early-phase study looks at how Acetadote, a drug that affects cell damage, changes metabolism in patients with newly diagnosed glioblastoma. Ten adults will receive Acetadote before surgery, and researchers will use MRI scans and tumor tissue analysis to measure metabolic ch…

This study looks at 30 people newly diagnosed with glioblastoma, a serious brain tumor. Researchers will compare special MRI brain scans with blood test results to find patterns. The goal is to better understand the tumor's environment without any direct treatment being tested.

This study looks at whether a special brain scan (PET-MRI) done within 48 hours after glioblastoma surgery is safe and practical. About 15 adults who just had their first surgery for suspected glioblastoma will get this scan. The goal is to see if it can find leftover tumor bette…

This study aims to understand why glioblastoma, a serious brain cancer, comes back after treatment. Researchers will analyze blood and tumor samples from 45 adults with newly diagnosed or recurrent glioblastoma. The goal is to identify key biological changes that could lead to be…

This study will look at medical records from 50 adults with glioblastoma, a fast-growing brain tumor. Researchers want to see how much of the tumor is removed during surgery and how that, along with standard chemotherapy and radiation, affects how long patients live. The goal is …

This early safety study tests a special MRI that uses pH (acid levels) to better see the edges of glioblastoma, a hard-to-treat brain tumor. Researchers will try to remove more of the tumor during surgery in 12 VA patients, focusing on whether this approach is safe and tolerable.…

This study will follow 100 adults with glioblastoma, a fast-growing brain tumor, to understand which factors (like surgery type, tumor features, and patient health) are linked to longer survival. Researchers will collect data from hospitals in Europe and the US but will not test …

This early study tests if a small device can safely collect fluid from the brain during planned surgery for glioma (a type of brain tumor) or epilepsy. Six adults will have the device placed temporarily during their operation. The main goals are to see if the procedure is safe an…

This early-phase trial will test whether an oral drug called gallium maltolate can reach brain tumor tissue in 8 people with recurrent glioblastoma. Participants take the drug before surgery, and researchers compare gallium levels in their removed tumor tissue to samples from unt…