GLIOBLASTOMA

This study tested whether adding a special immune cell therapy (Immuncell-LC) to standard chemotherapy (temozolomide) could better control a fast-growing brain cancer called glioblastoma. It involved 180 adults in Korea who were newly diagnosed and had recent surgery. Researchers…

This study compared two different surgical techniques for removing glioblastoma, a serious type of brain tumor. Researchers tested whether using a fluorescent dye that makes tumor cells glow under special light (fluorescence-guided surgery) was better than the standard computer n…

This early-stage study tested whether two existing drugs, given at low doses, could help control aggressive brain tumors that have returned after previous treatment. The goal was to see if the drugs could reduce certain immune cells that suppress the body's natural defenses again…

This study tested a personalized vaccine for adults newly diagnosed with glioblastoma, a very aggressive brain cancer. The vaccine was made from each patient's own tumor cells and given alongside standard chemotherapy and radiation. The main goal was to see if this combined appro…

This study tested a drug called VAL-083, given alongside standard radiation therapy, for people newly diagnosed with an aggressive brain cancer called glioblastoma (GBM). It focused on patients whose tumors have a specific genetic feature (unmethylated MGMT) that makes them less …

This pilot study tested whether using artificial intelligence (AI) maps to guide brain surgery could help patients with glioblastoma live longer. The AI was trained to predict where the aggressive brain tumor was most likely to regrow based on MRI scans. Surgeons used these maps …

This study tested whether a focused ultrasound device called ExAblate could safely and temporarily open the blood-brain barrier—a natural protective layer—in patients with aggressive brain tumors (glioblastoma). The goal was to see if opening this barrier could help standard chem…

This small pilot study tested whether adding a special light treatment during surgery is safe and practical for patients with glioblastoma, a serious brain cancer. Ten patients received the experimental light therapy right after their main tumor was removed, in addition to standa…

This study tested a combination of four treatments for patients whose aggressive brain cancer (glioblastoma) had returned. The goal was to see if using two immunotherapy drugs alongside radiation and a targeted therapy could help the immune system fight the cancer better, shrink …

This study tested whether adding two cannabis compounds (THC and CBD) to the standard treatment for glioblastoma, a very aggressive brain cancer, is safe and might help control the disease. Researchers worked with 33 adults newly diagnosed with this cancer to find the highest saf…

This early-stage study tested a new oral drug called TG02 for treating aggressive brain tumors (anaplastic astrocytoma and glioblastoma). It was given to elderly patients with newly diagnosed tumors alongside standard radiotherapy or chemotherapy, and to adults whose cancer had r…

This early-stage study tested a new mRNA vaccine called CVGBM in patients with an aggressive type of brain cancer called glioblastoma. The 37 participants had already undergone surgery and radiation treatment. Researchers gave patients seven vaccine injections over several weeks …

This early-stage study tested whether combining two existing cancer drugs (pembrolizumab and vorinostat) with standard chemotherapy and radiation is safe for people newly diagnosed with glioblastoma, an aggressive brain tumor. The trial involved 21 participants to determine the h…

This study tested whether adding whole-brain radiation therapy and a drug called plerixafor to the standard treatment could better control an aggressive type of brain tumor called glioblastoma (GBM). It involved 21 adults who had recently been diagnosed and had surgery. The main …

This study tested a light-based therapy given during surgery for glioblastoma, an aggressive brain cancer. It aimed to find the safest and most effective dose of light to use alongside standard surgery and chemo-radiation. The goal was to see if this combined approach could bette…

This study tested if two oral drugs, LY3214996 and abemaciclib, could reach brain tumors in people with recurrent glioblastoma. Up to 50 adults scheduled for surgery took the drugs before their operation so researchers could measure drug levels in the tumor tissue. The main goals…

This study tested a device that uses focused sound waves to temporarily open the protective blood-brain barrier. The goal was to see if this safe procedure could help standard chemotherapy drugs reach brain tumors more effectively in patients with glioblastoma. Researchers enroll…

This early-stage study tested the safety of combining three different treatments for newly diagnosed glioblastoma, a fast-growing brain cancer. It involved 12 adult patients who received a special electric field therapy, a short course of targeted radiation, and a chemotherapy dr…

This early-stage study tested a new combination of two immunotherapy drugs, ASP8374 and cemiplimab, in adults with an aggressive brain tumor that had returned. The main goals were to find the safest dose of the drug combo and to see if giving it right before surgery changed the i…

This completed Phase 2 trial tested whether adding a new drug called LY2157299 to standard lomustine chemotherapy, or using LY2157299 alone, could help people with recurrent glioblastoma brain cancer live longer compared to standard chemotherapy alone. The study involved 158 part…

This study tested whether adding a new immunotherapy drug (atezolizumab) to the standard treatment of chemotherapy and radiation could help patients with newly diagnosed glioblastoma, a very aggressive brain cancer. The goal was to see if this combination was safe and if it could…

This study tested the safety and effectiveness of combining two drugs, pembrolizumab and lenvatinib, in people with advanced solid tumors that had stopped responding to standard treatments. It involved 611 participants with cancers like triple-negative breast, ovarian, gastric, c…

This study tested whether two types of brain scans (PET and CT perfusion) could predict if patients with recurrent glioblastoma would respond to bevacizumab treatment. Researchers enrolled 14 patients whose brain cancer had returned after standard treatments. The goal was to see …

This study tested whether ramipril, a common blood pressure medication, could help prevent memory loss and thinking problems in people with glioblastoma (an aggressive brain cancer) who receive radiation and chemotherapy. Seventy-five participants took ramipril daily during their…

This study tested whether a talk therapy program for insomnia (CBT-I) is practical and helpful for people with primary brain tumors who have trouble sleeping. Researchers worked with 70 participants to see if they could successfully recruit people, deliver the therapy online, and…

This small pilot study tested whether a special type of brain scan (FDG PET/CT) could detect if chemotherapy was working in glioblastoma patients within 48 hours of starting treatment. Researchers wanted to see if early changes in how the tumor uses sugar (glucose), visible on th…

This study collected leftover tumor tissue and blood samples from 141 patients during their cancer surgery. Researchers analyzed these samples in the lab to understand how many living cancer cells could be recovered and studied. The goal is to gather information that will help sc…

This study aimed to find out if a simple blood test measuring platelet levels during the first phase of standard brain cancer treatment could predict which patients are at high risk for a dangerous drop in platelets later. Researchers followed 244 adults with glioblastoma to see …

This study aimed to find out if brain tumor (glioma) patients receiving oral chemotherapy at home were as satisfied with remote video visits (telehealth) as with traditional in-person clinic visits. It involved 30 patients who alternated between telehealth and in-person check-ups…

This small, early-stage study measured how much of the common painkiller lidocaine gets into brain tumors during surgery. Researchers took blood and tumor samples from 12 glioblastoma patients to understand how the drug moves through the body and tumor. The goal was to gather bas…

This study aimed to understand the nature of memory complaints in people with cancer, specifically brain tumors or breast cancer. Researchers compared 426 participants, including patients and healthy controls, to see if they reported more issues with remembering future plans (pro…