GLIOBLASTOMA

This early-stage trial tested an mRNA vaccine called CVGBM in 37 people with a fast-growing brain cancer (glioblastoma). Participants received the vaccine after surgery and radiation to see if it is safe and tolerable. The goal is to train the immune system to fight remaining can…

This study tested whether adding a metabolic therapy program (fasting and a ketogenic diet) to standard treatment (chemotherapy and radiation) is safe and feasible for people with glioblastoma, an aggressive brain tumor. The approach aims to starve cancer cells by lowering blood …

This study tested a personalized vaccine made from a patient's own tumor cells and immune cells (dendritic cells) for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the treatment is safe and can help delay tumor growth. 76 participant…

This early study tested if a focused ultrasound device can safely open the blood-brain barrier in 3 adults with aggressive brain tumors (glioblastoma) during standard chemotherapy. The goal was to see if the procedure is safe and can be repeated, potentially allowing more chemo t…

This study tested a drug called VAL-083 combined with standard radiation for people newly diagnosed with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the combination helps control th…

This study tested whether a device called ExAblate can safely and repeatedly open the blood-brain barrier in 20 adults with high-grade glioma (a serious brain cancer) who were already receiving standard chemotherapy. The goal was to allow chemotherapy drugs to better reach the tu…

This early-phase study tested a combination of two drugs (low-dose capecitabine and bevacizumab) in 12 people whose glioblastoma brain tumors had returned or worsened despite prior treatment. The goal was to see if the treatment could reduce certain immune cells (MDSCs) that help…

This study tested a new drug called LY2157299, either alone or combined with a standard chemotherapy (lomustine), in 158 adults whose glioblastoma (a type of brain cancer) had returned after initial treatment. The goal was to see if the new drug or combination could help patients…

This small pilot study tested whether adding a special light-based treatment during surgery is safe for people with glioblastoma, an aggressive brain cancer. Ten patients received the treatment along with standard care (surgery, radiation, and chemotherapy). The main goal was to …

This early-phase study tested a combination of three treatments for people newly diagnosed with glioblastoma, an aggressive brain cancer. The approach adds tumor treating fields (electric fields that disrupt cancer cell division) and focused radiation to standard chemotherapy. Th…

This study tested a new approach for people whose glioblastoma (a type of brain cancer) has come back after initial treatment. It combined focused radiation therapy with an immunotherapy drug called durvalumab, which helps the immune system fight cancer. The goal was to see if th…

This study tested a mix of two drugs (retifanlimab and epacadostat) plus radiation and bevacizumab in 51 people with recurrent glioblastoma, a serious brain cancer. The goal was to see if this combination could help the immune system fight the tumor and improve survival. While th…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers that had stopped responding to standard treatments. The cancers included triple-negative breast, ovarian, gastric, colorectal, glioblastoma, biliary tract, and pancreat…

This study tested whether adding whole brain radiation and a drug called plerixafor to standard chemotherapy can help people with a newly diagnosed aggressive brain tumor (glioblastoma). Twenty-one adults took part. The goal was to see if the combination could delay tumor growth …

This early-phase trial tested whether adding two drugs—pembrolizumab (an immunotherapy) and vorinostat (a targeted drug)—to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. The study enrolled 21 adults and focus…

This small pilot study tested a device called NaviFUS that uses focused ultrasound waves, combined with the standard drug bevacizumab, in 6 adults whose glioblastoma brain tumor had returned after prior treatment. The goal was to see if the combination was safe and could help con…

This study tested whether a 4-month ketogenic diet (high-fat, low-carb) is safe and doable for people with newly diagnosed glioblastoma, a serious brain cancer. Twenty-one adults followed personalized meal plans while receiving standard radiation and chemotherapy. Researchers tra…

This early-phase trial tested whether adding cannabis-derived THC and CBD to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. Thirty-three patients received increasing doses of the cannabis combination alongside…

This early-phase study tested two drugs, ASP8374 and cemiplimab, in 14 people with recurrent glioblastoma, an aggressive brain cancer. The goal was to find a safe dose and see if giving the drugs before surgery could increase cancer-fighting immune cells in the tumor. While not a…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation helps people with newly diagnosed glioblastoma, a fast-growing brain cancer. The trial enrolled 60 patients and focused on safety and survival. While the treatment aims to …

This study tested a new way to help surgeons remove glioblastoma, an aggressive brain tumor. Patients drank a special liquid (5-ALA) before surgery that makes tumor cells glow, helping surgeons see and remove more of the cancer. The study compared this glowing technique to the st…

This study tested whether artificial intelligence (AI) can help surgeons remove more of a glioblastoma brain tumor safely. The AI creates maps showing where the tumor is likely to come back, guiding the surgeon to remove extra tissue beyond the main tumor. Twenty patients with tu…

This early-phase study tested the drug TG02 in 71 patients with aggressive brain cancers (anaplastic astrocytoma or glioblastoma). It included older newly diagnosed patients and adults whose cancer had returned. The goal was to find the safest dose of TG02 when combined with eith…

This study tested a new way to treat glioblastoma, an aggressive brain cancer. During surgery to remove the tumor, doctors used a special light therapy (photodynamic therapy) to kill remaining cancer cells. The goal was to find the highest safe light dose. 14 patients took part, …

This study tested whether adding an immune cell therapy called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. The trial included 180 adults in Korea who had surgery for glioblastoma. Researchers mea…

This study tested whether the blood pressure medication Ramipril could help prevent memory loss in people with glioblastoma (a type of brain cancer) who are receiving radiation and chemotherapy. 75 participants took Ramipril during and for four months after their cancer treatment…

This study looked at whether a type of talk therapy called cognitive behavioral therapy for insomnia (CBT-I) can help people with brain tumors who have trouble sleeping. About 70 patients took part to see if the therapy was practical and helpful. The goal is to improve sleep and …

This study looked at how people with brain tumors or breast cancer perceive their own memory, especially the ability to remember to do things in the future (like taking medication). Over 400 participants completed questionnaires about memory, mood, and fatigue. The goal was to un…

This study looked at whether video doctor visits work as well as in-person visits for people with brain tumors (gliomas) who are taking oral chemotherapy. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which type of visit patient…

This study measured how much lidocaine, a common pain reliever, reaches the tumor and blood in 12 adults undergoing surgery for glioblastoma. The goal was to understand its movement in the body, not to treat the disease. Results may guide future treatment research.

This study looked at whether special brain scans (PET and CT perfusion) can predict if the drug bevacizumab will work in people whose glioblastoma brain cancer has come back. Fourteen patients were scanned before treatment to see if the scans could tell who would respond. The goa…

This study tested whether a costly PET scan called 18F-FDOPA helps doctors make better treatment choices for people with high-grade gliomas, a type of aggressive brain tumor. About 110 patients whose cases were discussed by a team of brain-tumor specialists took part. The main go…

This study looked at how well two drugs, LY3214996 and abemaciclib, get into the brain tumors of people with recurrent glioblastoma. About 42 participants took the drugs before surgery to remove their tumor. Researchers measured drug levels in the tumor tissue and spinal fluid to…

This study looked at whether using fluorescent dyes during brain tumor surgery helps surgeons remove more of the tumor. Researchers reviewed records of 41 patients with aggressive brain tumors treated at one hospital. They compared surgeries done with and without the dye to see i…

This study looked at brain tissue from 20 glioblastoma patients who had received tumor treatment fields (TTFields) therapy. Researchers examined the tissue after death to count active and inactive cancer cells. The goal was to understand how TTFields work at a cellular level, not…

This study looked at tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors. The goal was to measure cell counts and viability to help scientists develop better treatments in the future. Participants were already scheduled for surgery, and the stud…

This study looked at 47 adults with newly diagnosed glioblastoma or gliosarcoma to see if changes in immune cells in the blood could predict how well treatment works. Participants received a combination of immunotherapy drugs (ipilimumab and nivolumab) plus standard chemotherapy …

This study tested whether a special MRI technique can identify areas inside glioblastoma brain tumors that are rich in cancer stem cells. Researchers collected tissue samples from 21 patients during surgery and compared imaging data with lab tests. The goal was to learn more abou…

This small pilot study tested whether a special type of PET/CT scan (FDG PET/CT) can detect very early changes in brain tumors (glioblastoma) after starting chemotherapy. The idea is that tumors use sugar differently when they respond to treatment, and this scan measures sugar up…

This study involved 244 adults with newly diagnosed glioblastoma who were receiving standard chemoradiation (Stupp protocol). Researchers tracked platelet counts during treatment to see if changes could predict which patients would later develop dangerously low platelets (thrombo…