Zinc and cream combo may stop painful side effect of cancer treatment

NCT ID NCT06856590

Completed Symptom relief Sponsor: Gazi University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether taking zinc supplements and applying a strong steroid cream (clobetasol) can prevent or reduce hand-foot skin reaction, a common and painful side effect of the cancer drug regorafenib. About 150 patients starting regorafenib were split into three groups: zinc plus cream, cream alone, or zinc alone. Researchers tracked how many developed severe skin reactions over 8 weeks, aiming to find a simple way to keep patients comfortable on treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zinc gluconate and clobetasol propionate cream
What this could lead to: If it works, this could give cancer patients a simple way to avoid a painful side effect of regorafenib, helping them stay on treatment.
What could go wrong: This is a small, non-randomized study, so results may not be definitive. The treatments might not work for everyone or could cause their own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for GLIOBLASTOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm gastrointestinal stromal tumor glioblastoma hepatocellular carcinoma hand-foot syndrome prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HAND-FOOT SKIN REACTION (HFSR)

Contacts and locations

Locations

Afyonkarahisar University of Health Sciences Hospital

Afyonkarahisar, 03030, Turkey (Türkiye)
Ankara Etlik City Hospital

Ankara, Yenimahalle, 06170, Turkey (Türkiye)
Ankara University Faculty of Medicine Hospital

Ankara, 06230, Turkey (Türkiye)
Bursa Uludağ University Hospital

Bursa, Nilüfer, 16059, Turkey (Türkiye)
Dicle University Hospital

Diyarbakır, 21280, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, Yenimahalle, 06200, Turkey (Türkiye)
Gazi University

Ankara, Yenimahalle, 06500, Turkey (Türkiye)
Hacettepe University Faculty of Medicine Hospital

Ankara, 06230, Turkey (Türkiye)
Karadeniz Technical University Hospital

Trabzon, Ortahisar, 61080, Turkey (Türkiye)
Necmettin Erbakan University Meram Faculty of Medicine Hospital

Konya, Meram, 42080, Turkey (Türkiye)
Sakarya University Hospital

Sakarya, Serdivan, 54050, Turkey (Türkiye)
Tekirdağ Namık Kemal University Hospital

Tekirdağ, 59100, Turkey (Türkiye)
Van Yüzüncü Yıl University Dursun Odabaş Hospital

Van, 65080, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.