Could a High-Fat diet help fight brain cancer? early trial tests safety

NCT ID NCT03451799

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tested whether a 4-month ketogenic diet (a high-fat, low-carb diet) is safe and doable for people with newly diagnosed glioblastoma, a serious brain cancer. Twenty-one adults followed personalized meal plans while receiving standard radiation and chemotherapy. The main goals were to check for side effects like severe weight loss and to see if participants could maintain ketosis (a metabolic state). This trial does not yet prove the diet helps treat the cancer, but it aims to lay the groundwork for future studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ketogenic diet

What this could lead to

If successful, this could show that a ketogenic diet is safe and feasible alongside standard treatment, potentially pointing toward a way to improve outcomes for glioblastoma patients.

What could go wrong

This is a very early phase 1 trial with only 21 participants, focused on safety and feasibility, not effectiveness. The diet is demanding and may cause weight loss or other side effects, and it is unclear if it will help fight the cancer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Cedars Sinai Medical Center

    Los Angeles, California, 90048, United States