GLIOBLASTOMA

This early-phase study is testing whether adding an investigational drug called azeliragon to the standard initial treatment (radiation plus temozolomide chemotherapy) is safe for adults newly diagnosed with glioblastoma, an aggressive brain cancer. The main goal is to find a saf…

This early-phase study is testing the safety of a new two-drug combination (domvanalimab and zimberelimab) for adults with glioblastoma that has returned after initial treatment. The trial will enroll 46 patients to see how well the drugs are tolerated and to study their effects …

This early-stage study is testing whether adding an experimental drug called ruxolitinib to standard brain cancer treatment (radiation and chemotherapy) is safe for patients. Researchers want to find the highest dose of ruxolitinib that patients can tolerate without severe side e…

This study is testing whether adding an experimental drug called BPM31510 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to see if this combination can delay cancer progression and extend surv…

This study is testing whether a special high-fat, low-carbohydrate diet (ketogenic diet) combined with the diabetes medication metformin can help control aggressive brain tumors called glioblastomas. The approach aims to lower blood sugar levels, which might slow tumor growth. Re…

This early-phase study is testing whether a personalized vaccine made from a patient's own tumor, given alongside a device that uses electric fields to fight cancer (Tumor Treating Fields), is safe and well-tolerated. It involves 13 adults with newly diagnosed glioblastoma who ha…

This early-stage study is testing the safety of a new cell therapy for adults with aggressive brain cancers that have spread to the lining of the brain and spinal cord. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cell…

This study is testing a specialized, targeted form of radiation therapy for people with newly diagnosed brain tumors (gliomas). The goal is to see if this precise method can effectively treat the tumor while causing fewer side effects to the scalp, such as wound infections, hair …

This study is testing whether a personalized cell-based immunotherapy called IGV-001 can help control glioblastoma, a fast-growing brain cancer, and help patients live longer. The treatment is made from a patient's own tumor cells and is designed to train their immune system to f…

This early-stage trial is testing if adding high-dose vitamin C (given by IV) and an iron-based drug called ferumoxytol to the standard treatment for glioblastoma brain tumors is safe and helpful. The study involves about 17 adults who have just been diagnosed. The main goal is t…

This early-stage study is testing whether the drug niraparib can effectively reach brain tumors and slow their growth. It involves 42 adults with newly diagnosed glioblastoma or a specific type of recurrent brain cancer. The trial first checks if the drug gets into the tumor duri…

This study is testing whether an experimental capsule called vebreltinib (PLB1001) can help people live longer than standard chemotherapy for a specific type of recurrent brain cancer. It is for adults whose glioblastoma has returned and who have a particular genetic change calle…

This program provided expanded access to an investigational vaccine called SurVaxM for patients with glioblastoma, an aggressive brain cancer. It was for patients who had already completed a prior SurVaxM trial and wanted to continue, or for those with no access to other comparab…

This study is testing whether removing more tissue around an aggressive brain tumor (glioblastoma) during surgery helps patients live longer. It compares this more extensive 'supramarginal' surgery to the standard approach in 90 selected patients. The main goal is to see if takin…

This trial is testing whether combining a DNA vaccine (INO-5401 and INO-9012) with an immune checkpoint inhibitor drug (cemiplimab) can help fight newly-diagnosed glioblastoma, an aggressive brain cancer. The treatment is given alongside standard radiation and chemotherapy to 52 …

This study follows children and teens who are already taking the medications dabrafenib and/or trametinib for various types of brain tumors. The main goal is to monitor their long-term health, safety, and development while they continue treatment. Researchers will track side effe…

This trial is testing a new combination of immune-boosting drugs and cells injected directly into the brain tumor during surgery for patients whose glioblastoma has returned. The goal is to see if this targeted approach can better control the cancer while reducing side effects co…

This study is testing a new approach for treating glioblastoma when it returns after initial treatment. It compares a new method—using an implanted ultrasound device to temporarily open the brain's protective barrier so more chemotherapy can reach the tumor—against standard chemo…

This study is testing whether the drug olaparib can help control advanced cancers that have a specific genetic change (IDH1 or IDH2 mutation) and have stopped responding to standard treatments. It is enrolling adults with certain brain tumors, bile duct cancer, or other solid tum…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to the standard two-part treatment for glioblastoma can help patients live longer without their cancer getting worse. It will involve about 40 adults with newly diagnosed glioblastoma who have already had …

This is an early-stage safety study testing a new type of personalized cell therapy for aggressive brain tumors in adults and children. Doctors take a patient's own immune cells, modify them in a lab to better target and attack cancer cells that have a specific marker called CD70…

This early-stage trial is testing whether adding a drug called mycophenolate mofetil (MMF) to standard glioblastoma treatment is safe and might make the cancer more sensitive to chemotherapy. MMF is an immunosuppressant commonly used to prevent organ rejection after transplants. …

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This study is testing a new, more precise way to deliver radiation therapy to people newly diagnosed with glioblastoma, a fast-growing brain tumor. Doctors will use advanced MRI scans during treatment to target higher radiation doses specifically to the most resistant parts of th…

This early-stage study is testing a new drug called ST101 in patients with advanced solid tumors that cannot be surgically removed and have spread. The trial aims to find a safe and effective dose for cancers including glioblastoma, melanoma, breast cancer, and prostate cancer in…

This early-stage study is testing whether adding a strict, high-fat ketogenic diet to standard radiation and chemotherapy is safe and feasible for adults newly diagnosed with glioblastoma, an aggressive brain cancer. For 16 weeks, participants follow personalized meal plans desig…

This large Phase 3 trial is testing if adding a single, high dose of radiation directly to the tumor site during surgery helps people with newly diagnosed glioblastoma live longer without their cancer worsening. It compares standard post-surgery radiation and chemotherapy to the …

This study is testing whether adding an experimental vaccine called SurVaxM to standard chemotherapy (temozolomide) can help control a serious brain cancer called glioblastoma. The vaccine is designed to teach the body's immune system to recognize and attack cancer cells. The tri…

This study is testing if adding a new drug called anlotinib to the standard first treatment (the Stupp regimen) helps people with newly diagnosed glioblastoma live longer without their cancer getting worse. It's a Phase 2 trial involving 150 adults, where participants are randoml…

This study is testing whether adding two targeted drugs, dabrafenib and trametinib, after standard radiation therapy works better for children and young adults with a specific type of aggressive brain tumor. The treatment is for patients whose tumors have a particular genetic cha…

This is a small, early-stage study testing a personalized vaccine designed to train the immune system to fight a specific type of aggressive brain cancer called glioblastoma. The main goals are to see if creating and giving this custom vaccine is safe and possible, and to check i…

This is an early-stage study testing a new oral medication called gallium maltolate for adults with glioblastoma, a serious brain cancer, that has come back after standard treatments. The main goal is to find a safe dose and see if the drug shows any signs of helping control the …

This is an early-stage study testing the safety and feasibility of a new type of personalized cell therapy for adults with a specific, aggressive form of recurrent brain cancer called glioblastoma. The therapy involves modifying a patient's own immune cells (T cells) to target tw…

This early-stage study is testing whether adding the drug ibrutinib to standard radiation and chemotherapy (temozolomide) is safe for people newly diagnosed with glioblastoma, an aggressive brain cancer. Researchers want to find the highest safe dose of ibrutinib and see if radia…

This study is testing whether adding immune-boosting drugs (nivolumab and ipilimumab) to standard chemotherapy can help people with newly diagnosed glioblastoma, a very aggressive brain cancer. Researchers will track 47 adults who have already had surgery and initial treatment, l…

This study is testing if adding a new radiation implant called GammaTile during brain surgery can help control glioblastoma, a fast-growing and aggressive brain cancer. The implant, placed right after tumor removal, delivers radiation immediately and is combined with the standard…

This study is testing an experimental drug called abemaciclib for adults with glioblastoma, an aggressive brain cancer that has returned after initial treatment. The main goals are to see if the drug reaches the brain tumor effectively and if it can help slow the cancer's progres…

This early-stage trial is testing whether adding an experimental drug called selinexor to standard radiation and chemotherapy is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. Researchers want to find the highest dose of selinexor that patients can…

This early-stage study is testing a new radioactive drug called [177Lu]Lu-DOTA-TATE for adults with glioblastoma, a fast-growing brain cancer. For newly diagnosed patients, the drug is given alongside standard radiotherapy and chemotherapy. For patients whose cancer has returned,…

This study is testing if adding an immunotherapy drug called nivolumab to a standard re-treatment of radiation and the drug bevacizumab can help people with glioblastoma that has come back. It aims to see if this three-part combination helps patients live longer and keeps the can…

This is a first-in-human safety study testing a genetically engineered virus, rQNestin34.5v.2, as a potential treatment for recurrent malignant brain tumors (gliomas). The virus is designed to infect and kill only cancer cells while sparing healthy brain tissue. The main goals ar…

This study is testing a three-part treatment for glioblastoma, a serious brain cancer. It combines a new drug called paxalisib with a high-fat, low-carb ketogenic diet and metformin, a common diabetes medication. The goal is to see if this combination is safe and can help control…

This small pilot study is testing whether a strict low-sugar, high-fat diet (called an energy-restricted ketogenic diet) can help control glioblastoma, an aggressive brain cancer. The diet aims to 'starve' tumor cells by changing the body's energy sources while healthy brain cell…

This study is testing whether combining a pill called niraparib with a wearable device that delivers Tumor-Treating Fields (TTFields) can help control recurrent glioblastoma, a very aggressive brain cancer. The goal is to see if the device makes the tumor cells more vulnerable to…

This early-phase study is testing the safety and best dose of a personalized immune cell therapy for adults with recurrent or treatment-resistant malignant brain tumors (glioma). Doctors collect a patient's own immune cells, genetically modify them in a lab to recognize and attac…

This study is testing whether a pill called Tofacitinib can slow down the growth of glioblastoma, a very aggressive brain cancer, when it comes back after initial treatment. It involves 17 adults with recurrent cancer who will take the pills daily in 28-day cycles. Doctors will u…

This study is testing if adding a second chemotherapy drug, lomustine, to the current standard treatment helps people with a newly diagnosed, aggressive brain tumor live longer. It is for adults aged 18-70 with a specific tumor type (MGMT methylated glioblastoma) who have not had…

This study is comparing a new, shorter radiation schedule to the standard, longer one for treating glioblastoma, an aggressive brain cancer. Researchers want to see if the shorter treatment, which delivers higher doses over 1-2 weeks, works as well as the standard 3-6 week treatm…

This study is testing if delivering a higher, more concentrated dose of radiation directly to the brain tumor, using advanced techniques, can help patients with a serious brain cancer called glioblastoma live longer. Over 600 patients will receive either this intensified radiatio…

This is an early-stage study to see if adding an experimental drug called OKN-007 to the standard treatment (temozolomide and radiation) is safe and tolerable for people newly diagnosed with an aggressive brain cancer called glioblastoma. The main goal is to find the highest dose…

This program provided gallium maltolate (GaM) capsules to adults with glioblastoma that had returned or stopped responding to standard treatments. Patients took one capsule daily by mouth at home for 28-day cycles. The goal was to offer a potential treatment option when no other …

This early-stage trial is testing a new drug called AZD1390 in combination with standard radiation therapy for adults with aggressive brain tumors (grade 4 glioma or glioblastoma). The study first checks if the drug successfully reaches the tumor tissue. Patients whose tumors sho…

This early-stage study is testing a new two-drug combination (BGB-290 and temozolomide) for adolescents and young adults with specific types of brain tumors that have returned or are newly diagnosed. The main goal is to find the safest dose and understand the side effects. Resear…

This study is testing whether adding an immunotherapy drug called indoximod to standard chemotherapy and radiation can better control aggressive brain tumors in children and young adults. It is for patients aged 3 to 21 with certain progressive brain cancers or a newly diagnosed,…

This study is testing whether adding a new drug called veliparib to the standard treatment of radiation and chemotherapy can better control aggressive brain tumors in children and young adults. The trial is for patients aged 3-25 with newly diagnosed high-grade gliomas who have s…

This early-stage trial is testing whether giving immunotherapy drugs before surgery helps the body's immune system fight recurrent glioblastoma, a fast-growing brain cancer. About 63 participants will receive either one drug, a combination of two drugs, or a placebo before their …

This study is testing whether adding an experimental drug called veliparib to standard chemotherapy (temozolomide) helps patients with newly diagnosed glioblastoma, a fast-growing brain cancer, live longer. About 447 patients whose tumors have a specific genetic feature (MGMT pro…

This study is testing an online meditation and breathing program designed for couples where one person has a brain tumor. The goal is to see if the program is practical and helps improve spiritual well-being, sleep, mood, and overall quality of life for both the patient and their…

This study aims to determine if advanced MRI scans can predict which patients with newly diagnosed glioblastoma (an aggressive brain cancer) will respond best to Optune therapy. Researchers will compare standard and advanced MRI images from 60 patients receiving Optune plus chemo…

This study aims to understand how doctors communicate with patients who have glioblastoma, a serious brain cancer, and their caregivers. Researchers are observing conversations about scan results, treatment options, and difficult topics like prognosis and end-of-life care. The go…

This study aims to gather information to help design a new type of immunotherapy for glioblastoma, a serious brain cancer. Researchers will track 40 patients to understand how and why their cancer-fighting immune cells get trapped in the bone marrow, away from the tumor. The goal…

This early study aims to see if two new oral drugs, defactinib or VS-6766, can reach brain tumors in patients with glioblastoma. Researchers will give a single dose to 14 patients before their scheduled tumor removal surgery. The main goals are to measure how much drug gets into …

This study aims to understand which treatment sequences work best for patients whose aggressive brain tumors have returned. Researchers will analyze the medical records of about 1,000 patients to see how different chemotherapy and targeted drug combinations affect survival and ti…