Brain cancer patients get new hope: electric fields plus immunotherapy tested in major trial

NCT ID NCT06556563

Recruiting now Disease control Sponsor: NovoCure GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether adding an immunotherapy drug (pembrolizumab) to standard treatment (tumor-treating electric fields plus chemotherapy) helps people with newly diagnosed glioblastoma live longer. About 741 adults who have had surgery for glioblastoma will be randomly assigned to receive either the immunotherapy or a placebo, along with the standard therapy. The main goal is to see if the combination improves overall survival.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Addenbrooke's Hospital (Cambridge University Hospitals NHS Foundation Trust)
ACTIVE_NOT_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
CHUM
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Centre Hospitalier Universitaire Vaudois (CHUV)
ACTIVE_NOT_RECRUITING

Lausanne, 1005, Switzerland
Centre Hospitalier Universitaire de Lyon
ACTIVE_NOT_RECRUITING

Bron, 69500, France
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie-CHUS)
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Centrum Onkologii
ACTIVE_NOT_RECRUITING

Bydgoszcz, 85-796, Poland
Chaim Sheba Medical Center
ACTIVE_NOT_RECRUITING

Ramat Gan, 5265601, Israel
Charing Cross Hospital
ACTIVE_NOT_RECRUITING

London, Greater London, W6 8RF, United Kingdom
Charité Campus Virchow-Klinikum
ACTIVE_NOT_RECRUITING

Berlin, 10117, Germany
Columbia University Irving Medical Center
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Duke University Medical Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Fondazione IRCCS Istituto Neurologico Carlo Besta
ACTIVE_NOT_RECRUITING

Milan, 20133, Italy
Fujita Health University Hospital
RECRUITING

Toyoake-shi, Aichi-ken, 470-1192, Japan
Groupe Hospitalier Pitie - Salpetriere
ACTIVE_NOT_RECRUITING

Paris, 75013, France
Hamilton Health Sciences-Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Hoag Memorial Hospital Presbyterian
ACTIVE_NOT_RECRUITING

Newport Beach, California, 92663, United States
Hokkaido University Hospital
RECRUITING

Hokkaido, 060-8648, Japan

Contact Email: •••••@•••••
Hopital Saint-Louis
ACTIVE_NOT_RECRUITING

Paris, 75010, France
Hopital de la Timone
ACTIVE_NOT_RECRUITING

Marseille, 13385, France
Hospital Universitari Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politécnic La Fe
ACTIVE_NOT_RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
ACTIVE_NOT_RECRUITING

Madrid, 28041, Spain
Hospital Universitario Clínico San Carlos
ACTIVE_NOT_RECRUITING

Madrid, Madrid, 28040, Spain
Hospital Universitario La Paz
ACTIVE_NOT_RECRUITING

Madrid, 28046, Spain
Hospital Universitario Ramón y Cajal
ACTIVE_NOT_RECRUITING

Madrid, 28034, Spain
Hospital Universitario Reina Sofia
ACTIVE_NOT_RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Virgen de las Nieves
ACTIVE_NOT_RECRUITING

Granada, 18014, Spain
Hospital Universitario Virgen del Rocio
ACTIVE_NOT_RECRUITING

Seville, 41013, Spain
Huntsman Cancer Institute, University of Utah
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS Istituto Clinico Humanitas
ACTIVE_NOT_RECRUITING

Rozzano, 20089, Italy
Inova Schar Cancer Institute
ACTIVE_NOT_RECRUITING

Fairfax, Virginia, 22031, United States
Institut Català d'Oncologia de L'Hospitalet (ICO L'Hospitalet)
ACTIVE_NOT_RECRUITING

Barcelona, 08908, Spain
Institut Claudius Regaud
ACTIVE_NOT_RECRUITING

Toulouse, 31059, France
John Theurer Cancer Center/ Hackensack Meridian Health
ACTIVE_NOT_RECRUITING

Hackensack, New Jersey, 07601, United States
Kanazawa University Hospital
RECRUITING

Ishikawa, 920-8641, Japan

Contact Email: •••••@•••••
Kumamoto University Hospital
RECRUITING

Kumamoto, 860-8556, Japan

Contact Email: •••••@•••••
Kyorin University Hospital
RECRUITING

Mitaka, 181-8611, Japan

Contact Email: •••••@•••••
Kyoto University Hospital
RECRUITING

Kyoto, 606-8507, Japan

Contact Email: •••••@•••••
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan

Contact Email: •••••@•••••
Masonic Cancer Center, University of Minnesota
ACTIVE_NOT_RECRUITING

Minneapolis, Minnesota, 55455, United States
Mayo Clinic - Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85054, United States
MedStar Georgetown University Hospital
ACTIVE_NOT_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Miami Cancer Institute
ACTIVE_NOT_RECRUITING

Miami, Florida, 33176, United States
Moffitt Cancer Center
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Center- Montefiore Medical Park
ACTIVE_NOT_RECRUITING

The Bronx, New York, 10461, United States
Montreal Neurological Institute-Hospital, Clinical Research Unit
RECRUITING

Montreal, Quebec, H3A 2B4, Canada
Mount Vernon Cancer Centre
ACTIVE_NOT_RECRUITING

Northwood, Middlesex, HA6 2RN, United Kingdom
Nagoya University Hospital
RECRUITING

Nagoya, 466-8560, Japan

Contact Email: •••••@•••••
Narodowy Instytut Onkologii
ACTIVE_NOT_RECRUITING

Gliwice, 44-102, Poland
National Cancer Center Hospital
RECRUITING

Tokyo, 104-0045, Japan

Contact Email: •••••@•••••
Nemocnice Na Homolce
ACTIVE_NOT_RECRUITING

Prague, 150 30, Czechia
Neuro-Oncologia Clinica Ospedale Molinette - AOU Città della Salute e della Scienza di Torino
ACTIVE_NOT_RECRUITING

Torino, Torino, 10126, Italy
Northwell Health
ACTIVE_NOT_RECRUITING

Lake Success, New York, 11042, United States
Northwestern Memorial Hospital
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Norton Cancer Institute
ACTIVE_NOT_RECRUITING

Louisville, Kentucky, 40241, United States
Ospedale Bellaria
ACTIVE_NOT_RECRUITING

Bologna, 40139, Italy
Ospedale del Mare
ACTIVE_NOT_RECRUITING

Naples, 80147, Italy
Queen Elizabeth
ACTIVE_NOT_RECRUITING

Birmingham, B15 2TH, United Kingdom
Rabin Medical Center- Beilinson Hospital
ACTIVE_NOT_RECRUITING

Petah Tikva, 4941492, Israel
Rambam Medical Center
ACTIVE_NOT_RECRUITING

Haifa, 3109601, Israel
Renown Regional Medical Center
ACTIVE_NOT_RECRUITING

Reno, Nevada, 89502, United States
Rhode Island Hospital
ACTIVE_NOT_RECRUITING

Providence, Rhode Island, 02903, United States
Royal Marsden
ACTIVE_NOT_RECRUITING

Sutton, SM2 5PT, United Kingdom
Rutgers Cancer Institute of New Jersey University Hospital
ACTIVE_NOT_RECRUITING

New Brunswick, New Jersey, 08901, United States
Saitama Medical University International Medical Center
RECRUITING

Saitama, 350-1298, Japan

Contact Email: •••••@•••••
Southampton General Hospital
ACTIVE_NOT_RECRUITING

Southampton, SO16 6YD, United Kingdom
Stanford Cancer Institute
ACTIVE_NOT_RECRUITING

Palo Alto, California, 94305, United States
Swedish Medical Center
ACTIVE_NOT_RECRUITING

Seattle, Washington, 98122, United States
Tel-Aviv Sourasky Medical Center
ACTIVE_NOT_RECRUITING

Tel Aviv, 64239, Israel
The Christie Hospital
ACTIVE_NOT_RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre (Clatterbridge Cancer Centre NHS Foundation Trust)
ACTIVE_NOT_RECRUITING

Liverpool, L7 8YA, United Kingdom
The Cleveland Clinic
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44195, United States
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The University of Texas
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Clinical Trials Organization
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tohoku University Hospital
RECRUITING

Sendai, 980-8574, Japan

Contact Email: •••••@•••••
Tokai University Hospital
RECRUITING

Isehara, Kanagawa, 259-1193, Japan
Tufts Medical Center
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02111, United States
U.O.C. Immunoterapia Oncologica A.O.U. Senese, Policlinico Santa Maria alle Scotte
ACTIVE_NOT_RECRUITING

Siena, 53100, Italy
UF Health Neuromedicine
ACTIVE_NOT_RECRUITING

Gainesville, Florida, 32608, United States
UOC Oncologia Medica 1 Istituto Oncologico Veneto IOV-IRCCS
ACTIVE_NOT_RECRUITING

Padova, 35128, Italy
UPMC Hillman Cancer Center
ACTIVE_NOT_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University Health Network - Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C1, Canada
University Hospital Basel Medical Oncology
ACTIVE_NOT_RECRUITING

Basel, 4031, Switzerland
University Hospital Frankfurt
ACTIVE_NOT_RECRUITING

Frankfurt, 60528, Germany
University Hospital Zurich
ACTIVE_NOT_RECRUITING

Zurich, 8091, Switzerland
University Hospitals Cleveland Medical Center
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44106, United States
University of California
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
University of Cincinnati Cancer Institute
ACTIVE_NOT_RECRUITING

Cincinnati, Ohio, 45219, United States
University of Kentucky Medical Center
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21201, United States
University of Southern California
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90033, United States
University of Texas, MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Universitätsklinikum Essen
ACTIVE_NOT_RECRUITING

Essen, 45147, Germany
Velindre Cancer Centre
ACTIVE_NOT_RECRUITING

Cardiff, CF14 2TL, United Kingdom
Washington University
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63110, United States
Western General Hospital
ACTIVE_NOT_RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Weston Park Hospital
ACTIVE_NOT_RECRUITING

Sheffield, S10 2SJ, United Kingdom
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika-Zakład Teleradioterapii
ACTIVE_NOT_RECRUITING

Lodz, 93-513, Poland

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