Sound waves open brain barrier to attack deadly tumor

NCT ID NCT05902169

Recruiting now Disease control Sponsor: CarThera Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 14 times

Summary

This Phase 3 trial tests a device called SonoCloud-9, which uses ultrasound to temporarily open the blood-brain barrier, allowing more carboplatin chemotherapy to reach glioblastoma tumors that have returned after initial treatment. About 560 participants will be randomly assigned to receive either the SonoCloud-9 with carboplatin or standard chemotherapy (lomustine or temozolomide). The main goal is to see if the combination improves overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin (chemotherapy) delivered with SonoCloud-9 ultrasound device to open the blood-brain barrier
What this could lead to: If successful, this could offer a new treatment option for recurrent glioblastoma by allowing more chemotherapy to reach the brain tumor, potentially improving survival.
What could go wrong: This is a Phase 3 trial, but the approach is novel and may not improve outcomes over standard care. Risks include side effects from chemotherapy and potential complications from the implanted ultrasound device.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GBM GLIOBLASTOMA RECURRENT GLIOBLASTOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Akademiska sjukhuset
RECRUITING

Uppsala, 75185, Sweden
Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino
RECRUITING

Torino, 10126, Italy
CHU de Liège
RECRUITING

Liège, Belgium
Centre Hospitalier Universitaire Vaudois (CHUV)
ACTIVE_NOT_RECRUITING

Lausanne, 1011, Switzerland
Charité Universitätsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Erasmus Medisch Centrum (Erasmus MC)
RECRUITING

Rotterdam, Netherlands
Haaglanden Medisch Centrum
RECRUITING

The Hague, 2263, Netherlands
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hôpital Foch
RECRUITING

Suresnes, 92150, France
Hôpital Neurologique Pierre Wertheimer
RECRUITING

Bron, France
Hôpital de La Timone
RECRUITING

Marseille, France
Hôpital de la Pitié-Salpêtrière
RECRUITING

Paris, France
IFO - Istituto Nazionale Tumori Regina Elena
RECRUITING

Roma, Italy
Indiana University Health
RECRUITING

Indianapolis, Indiana, 46202, United States
Inselspital Bern
ACTIVE_NOT_RECRUITING

Bern, 3010, Switzerland
Irccs Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Oncologico Veneto
RECRUITING

Padua, Italy
John Hopkins University
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21287, United States
Kaiser Permanente
NOT_YET_RECRUITING

Los Angeles, California, 90027, United States
Klinikum Chemnitz gGmbH
RECRUITING

Chemnitz, 09113, Germany
Lennox Hill Hospital
RECRUITING

New York, New York, 10075, United States
Mayo Clinic Arizona
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 805054, United States
Mayo Clinic Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic of Jacksonville Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Medizinische Universitaet Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Neurochirurgie uniklinik Köln
RECRUITING

Cologne, Germany
Neurological Institute Brain Tumor Centre Taussig Cancer Cente
RECRUITING

Cleveland, Ohio, 44106, United States
NewYork-Presbyterian / Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Odense University Hospital
RECRUITING

Odense, 5000, Denmark
Ospedale Bellaria
RECRUITING

Bologna, 40139, Italy
Ospedale Civile di Livorno
RECRUITING

Livorno, 57124, Italy
Penn State Health Milton S. Hershey Medical Center
ACTIVE_NOT_RECRUITING

Hershey, Pennsylvania, 17033, United States
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Sutter Health - California Pacific Medical Center
RECRUITING

San Francisco, California, 94109, United States
UCHealth
RECRUITING

Aurora, Colorado, 80011, United States
UCLA
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, Belgium
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, Belgium
University of California, San Francisco
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27516, United States
University of Texas Houston Health Science Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Utah, Hunstman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Universitätsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Essen Klinik für Neurologie
RECRUITING

Essen, 45147, Germany
Vall d'Hebron Institute of Oncology (VHIO)
RECRUITING

Barcelona, 08035, Spain
Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Winship Cancer Institute at Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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