New radioactive drug takes aim at Hard-to-Treat cancers
NCT ID NCT05283330
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new drug that delivers radiation directly to cancer cells carrying a specific protein called GRPR. The study includes 48 adults with advanced cancers like prostate, breast, lung, or colon cancer that have not responded to standard treatments. The main goal is to find a safe dose and check for early signs that the drug is working.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A radioactive drug (212Pb-DOTAM-GRPR1) that targets a protein called GRPR found on some cancer cells
- What this could lead to
- If it works, this could offer a new treatment option for people with advanced cancers that have the GRPR protein, especially when other treatments have stopped working.
- What could go wrong
- This is a very early, first-in-human trial with only 48 participants. The drug may not shrink tumors or could cause side effects from radiation. Success is far from guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Advanced Molecular Imaging and Therapy
RECRUITINGGlen Burnie, Maryland, 21061, United States
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Nebraska Cancer Specialists (Midwest Cancer Center - Legacy)
RECRUITINGOmaha, Nebraska, 68130, United States
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Northwestern University Robert H Lurie Medical Research
ACTIVE_NOT_RECRUITINGChicago, Illinois, 60611, United States
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UK Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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United Theranostics - Chesapeake
NOT_YET_RECRUITINGGlen Burnie, Maryland, 21061, United States
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University of Iowa Health Care
NOT_YET_RECRUITINGIowa City, Iowa, 52242, United States
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University of Pittsburg Medical Center (UPCM)
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15219, United States
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XCancer Omaha / Urology Cancer Center
RECRUITINGOmaha, Nebraska, 68130, United States
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