MALIGNANT GLIOMA

This early-phase trial tests a new treatment for adults with glioblastoma or other high-grade gliomas that have come back after standard therapy. The treatment uses specially engineered immune cells (CAR-NK cells) that are designed to target two different markers on tumor cells a…

This early-phase study tests whether giving a single, precise dose of radiation before surgery can improve control of high-grade gliomas (aggressive brain tumors) while reducing side effects. About 28 adults with newly diagnosed or previously biopsied high-grade glioma will recei…

This early-phase study tests a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a fast-growing brain cancer that has come back. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack the tumor. The main goals are to …

This early-phase study tests a new treatment for adults with glioblastoma or high-grade glioma that has come back after standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to target two different markers on tumor cells at once, which may h…

This study tests a drug called selinexor combined with standard radiation for children and young adults with newly diagnosed DIPG or high-grade glioma. The goal is to find a safe dose and see if the combination can shrink tumors. About 132 participants will take part in two phase…

This early-stage study tests whether a special ultrasound device can safely open the blood-brain barrier in children with hard-to-treat brain tumors. The goal is to let chemotherapy reach the tumor more effectively. About 24 children aged 5 to 17 will receive ultrasound before th…

This study tests a special dye that attaches to brain tumor cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma wi…

This study looks at whether a low-carb diet (modified Atkins) combined with a supervised exercise program can improve quality of life and physical fitness in people with malignant glioma. Fifteen participants will follow the program for 15 weeks. The goal is to see if this approa…

This study uses special MRI scans to map electrical activity in the brain. Researchers will compare scans from healthy volunteers and people with brain tumors (glioma) to see if the new method can help improve diagnosis. The goal is to better understand how electrical signals tra…

This early phase trial at Mayo Clinic is studying how two drugs, DFMO and AMXT 1501, change the metabolism of brain tumors (gliomas) in 18 adult patients. The goal is to measure molecules in the tumor's fluid to understand how these drugs affect tumor growth and survival. This st…

This study looks at whether having additional MRI scans during radiation and chemotherapy can help doctors see changes in high-grade glioma (a type of brain tumor) early. By spotting these changes, doctors may be able to adjust the treatment plan to better target the tumor and pr…

This study looks at whether special MRI scans and blood tests can help predict how a severe type of brain tumor (grade IV glioma) changes over time. Researchers will track 15 adults with newly diagnosed tumors to see if iron-related markers in the body signal tumor growth. The go…

This study tests a new MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. Researchers will compare MRI results with tissue samples from 30 adults who are already scheduled for tumor removal. The goal is to improve how doctors track a…