Ultrasound 'Key' may let chemo reach Kids' brain tumors
NCT ID NCT05293197
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests whether a device called SonoCloud-9 can safely open the blood-brain barrier in children aged 5 to 17 with recurrent malignant brain tumors. The barrier normally blocks chemotherapy from reaching the brain. By using low-intensity ultrasound just before giving the drug carboplatin, researchers hope to boost treatment effectiveness. The study involves 24 participants and focuses on safety, including risks like bleeding or seizures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
carboplatin (chemotherapy) delivered after ultrasound opening of the blood-brain barrier using the SonoCloud-9 device
What this could lead to
If it works, this could make chemotherapy more effective for children with hard-to-treat brain tumors by temporarily opening the blood-brain barrier.
What could go wrong
This is a very early (Phase 1) safety trial with only 24 children, so it may not improve survival. Risks include bleeding, brain swelling, or seizures from the ultrasound procedure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institut Curie
RECRUITINGParis, 75005, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Gustave Roussy
RECRUITINGVillejuif, 94800, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Service de neurochirugie Pédiatrique - Hôpital Necker- Enfants Malades
RECRUITINGParis, 75015, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••