Ultrasound 'Key' may let chemo reach Kids' brain tumors

NCT ID NCT05293197

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether a device called SonoCloud-9 can safely open the blood-brain barrier in children aged 5 to 17 with recurrent malignant brain tumors. The barrier normally blocks chemotherapy from reaching the brain. By using low-intensity ultrasound just before giving the drug carboplatin, researchers hope to boost treatment effectiveness. The study involves 24 participants and focuses on safety, including risks like bleeding or seizures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: carboplatin (chemotherapy) delivered after ultrasound opening of the blood-brain barrier using the SonoCloud-9 device
What this could lead to: If it works, this could make chemotherapy more effective for children with hard-to-treat brain tumors by temporarily opening the blood-brain barrier.
What could go wrong: This is a very early (Phase 1) safety trial with only 24 children, so it may not improve survival. Risks include bleeding, brain swelling, or seizures from the ultrasound procedure.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor brain cancer embryonal neoplasm ependymoma glioma malignant glioma Neoplasms, Germ Cell and Embryonal

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMBRYONAL TUMOR MALIGNANT BRAIN TUMOR MALIGNANT GLIOMA

Contacts and locations

Locations

Institut Curie
RECRUITING

Paris, 75005, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Service de neurochirugie Pédiatrique - Hôpital Necker- Enfants Malades
RECRUITING

Paris, 75015, France

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