New combo therapy hopes to fight deadly childhood brain cancers

NCT ID NCT05099003

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 18 times

Summary

This trial tests a drug called selinexor combined with standard radiation in children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) that has a specific genetic change (H3 K27M mutation). The study has two parts: first, finding the safest dose of selinexor, then seeing how well it works to shrink tumors. About 132 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: selinexor (a drug that blocks a protein called CRM1 to stop cancer cell growth)
What this could lead to: If it works, this could point toward a new treatment option for children with these aggressive brain tumors, potentially improving survival.
What could go wrong: This is an early-phase trial (phase 1/2) with a small number of participants, so the drug may not work or could cause severe side effects. The tumors are very hard to treat, so success is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse intrinsic pontine glioma glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT GLIOMA

Contacts and locations

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Locations

Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202-3591, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
BI-LO Charities Children's Cancer Center
RECRUITING

Greenville, South Carolina, 29605, United States
Banner Children's at Desert
RECRUITING

Mesa, Arizona, 85202, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Blank Children's Hospital
RECRUITING

Des Moines, Iowa, 50309, United States
British Columbia Children's Hospital
SUSPENDED

Vancouver, British Columbia, V6H 3V4, Canada
C S Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
RECRUITING

Québec, G1V 4G2, Canada
CancerCare Manitoba
SUSPENDED

Winnipeg, Manitoba, R3E 0V9, Canada
Cardinal Glennon Children's Medical Center
RECRUITING

St Louis, Missouri, 63104, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Centre Hospitalier Universitaire Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital Medical Center of Akron
RECRUITING

Akron, Ohio, 44308, United States
Children's Hospital New Orleans
RECRUITING

New Orleans, Louisiana, 70118, United States
Children's Hospital and Medical Center of Omaha
RECRUITING

Omaha, Nebraska, 68114, United States
Children's Hospital of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States

Contact Email: •••••@•••••
Children's Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States

Contact Email: •••••@•••••
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Hospital of Pittsburgh of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters
RECRUITING

Norfolk, Virginia, 23507, United States

Contact Email: •••••@•••••
Children's Hospital of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States

Contact Email: •••••@•••••
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Christchurch Hospital
RECRUITING

Christchurch, 8011, New Zealand
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

Contact Email: •••••@•••••
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106, United States
Cook Children's Medical Center
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dayton Children's Hospital
RECRUITING

Dayton, Ohio, 45404, United States
Dell Children's Medical Center of Central Texas
RECRUITING

Austin, Texas, 78723, United States
Driscoll Children's Hospital
RECRUITING

Corpus Christi, Texas, 78411, United States
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
East Tennessee Childrens Hospital
RECRUITING

Knoxville, Tennessee, 37916, United States
Eastern Maine Medical Center
RECRUITING

Bangor, Maine, 04401, United States
El Paso Children's Hospital
RECRUITING

El Paso, Texas, 79905, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Golisano Children's Hospital of Southwest Florida
RECRUITING

Fort Myers, Florida, 33908, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hospital for Sick Children
SUSPENDED

Toronto, Ontario, M5G 1X8, Canada
IWK Health Centre
RECRUITING

Halifax, Nova Scotia, B3K 6R8, Canada

Contact Email: •••••@•••••
Jim Pattison Children's Hospital
SUSPENDED

Saskatoon, Saskatchewan, S7N 0W8, Canada
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kaiser Permanente-Oakland
RECRUITING

Oakland, California, 94611, United States
Kapiolani Medical Center for Women and Children
RECRUITING

Honolulu, Hawaii, 96826, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

Contact Email: •••••@•••••
Legacy Emanuel Children's Hospital
RECRUITING

Portland, Oregon, 97227, United States
Loma Linda University Medical Center
RECRUITING

Loma Linda, California, 92354, United States
Lucile Packard Children's Hospital Stanford University
RECRUITING

Palo Alto, California, 94304, United States
Maine Children's Cancer Program
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Mary Bridge Children's Hospital and Health Center
RECRUITING

Tacoma, Washington, 98405, United States

Contact Email: •••••@•••••
McMaster Children's Hospital at Hamilton Health Sciences
SUSPENDED

Hamilton, Ontario, L8N 3Z5, Canada
Medical City Dallas Hospital
RECRUITING

Dallas, Texas, 75230, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Miami Cancer Institute
ACTIVE_NOT_RECRUITING

Miami, Florida, 33176, United States
Miller Children's and Women's Hospital Long Beach
RECRUITING

Long Beach, California, 90806, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Nemours Children's Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital
RECRUITING

Orlando, Florida, 32827, United States
Newark Beth Israel Medical Center
RECRUITING

Newark, New Jersey, 07112, United States
Norton Children's Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

Contact Email: •••••@•••••
Novant Health Presbyterian Medical Center
RECRUITING

Charlotte, North Carolina, 28204, United States
OSF Children's Hospital of Illinois
RECRUITING

Peoria, Illinois, 61637, United States

Contact Email: •••••@•••••
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Perth Children's Hospital
RECRUITING

Perth, Western Australia, 6009, Australia

Contact Email: •••••@•••••
Phoenix Childrens Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Prisma Health Richland Hospital
RECRUITING

Columbia, South Carolina, 29203, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
RECRUITING

Toledo, Ohio, 43606, United States

Contact Email: •••••@•••••
Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING

Spokane, Washington, 99204, United States
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia
Rady Children's Hospital - San Diego
RECRUITING

San Diego, California, 92123, United States
Rainbow Babies and Childrens Hospital
SUSPENDED

Cleveland, Ohio, 44106, United States
Rhode Island Hospital
SUSPENDED

Providence, Rhode Island, 02903, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46202, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Royal Children's Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
RECRUITING

New Brunswick, New Jersey, 08903, United States
Saint Christopher's Hospital for Children
RECRUITING

Philadelphia, Pennsylvania, 19134, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
RECRUITING

Tampa, Florida, 33607, United States
Saint Joseph's Regional Medical Center
RECRUITING

Paterson, New Jersey, 07503, United States
Saint Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Starship Children's Hospital
RECRUITING

Grafton, Auckland, 1145, New Zealand
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Sydney Children's Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
The Children's Hospital at TriStar Centennial
RECRUITING

Nashville, Tennessee, 37203, United States
The Children's Hospital at Westmead
RECRUITING

Westmead, New South Wales, 2145, Australia
The Montreal Children's Hospital of the MUHC
RECRUITING

Montreal, Quebec, H3H 1P3, Canada

Contact Email: •••••@•••••
The Steven and Alexandra Cohen Children's Medical Center of New York
RECRUITING

New Hyde Park, New York, 11040, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States

Contact Email: •••••@•••••
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada

Contact Email: •••••@•••••
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Minnesota/Masonic Cancer Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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