MALIGNANT GLIOMA

This study looks at whether a wearable device called Optune is safe and practical for children with aggressive brain tumors. In one group, kids with recurrent high-grade glioma or ependymoma use the device alone. In another group, children with newly diagnosed DIPG use the device…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This study tests the drug nivolumab in 62 adults with a type of brain tumor (glioma) that has specific gene changes (IDH mutations). The goal is to see if nivolumab can stop or slow tumor growth. Participants receive the drug through an IV every few weeks and are monitored with s…

This study tests whether two targeted drugs, dabrafenib and trametinib, given after radiation therapy can help children and young adults (up to age 25) with a specific type of aggressive brain cancer called BRAF V600-mutant high-grade glioma. The drugs block signals that help can…

This study tests whether adding the drug veliparib to standard radiation and chemotherapy can help children and young adults with a fast-growing brain tumor called high-grade glioma. Veliparib blocks a protein that helps cancer cells repair themselves, potentially making treatmen…

This early-stage study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in adolescents and young adults with IDH-mutant gliomas, a type of brain tumor. The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnosed o…

This early-stage trial tests a new immune cell therapy for people with recurrent or treatment-resistant malignant glioma, a type of brain cancer. The therapy uses the patient's own T cells, which are modified in the lab to recognize and attack cancer cells. The main goals are to …

This early-stage trial is testing the safety and early effectiveness of a drug called pembrolizumab in children and young adults whose aggressive brain tumors have come back or stopped responding to standard treatments. The drug is a type of immunotherapy designed to help the bod…

This study tests a new type of MRI scan that looks at sodium and other signals in the brain to better understand tumors. It includes healthy volunteers and people with brain tumors (glioma). The goal is to improve how doctors detect and monitor these tumors, which could lead to b…

This study tests an online mind-body program for people with brain tumors (glioma or cancer spread to the brain) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life. About 74 couples will take part to see if the program i…

This study looks at whether adding a special PET scan (18F-DOPA) to the usual MRI can help doctors better plan radiation treatment for people with certain brain tumors (malignant glioma). About 25 participants will have both scans, and researchers will compare how well each ident…

This study screens children and young adults (ages 1-21) with advanced solid tumors, lymphomas, or related disorders that have not responded to standard therapy. Researchers analyze the genetic makeup of each patient's tumor to find specific mutations that can be targeted by cert…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …