MALIGNANT GLIOMA

This pilot study is testing whether combining a modified Atkins diet (low-carb, high-protein) with a 12-week fitness program can improve quality of life and physical function in 15 people with malignant glioma. Participants will follow the diet and attend two supervised exercise …

This study tested a new drug called veliparib, given with radiation and chemotherapy, for children and young adults with a fast-growing brain tumor (high-grade glioma). The goal was to see if adding veliparib helps keep the cancer from coming back longer than standard treatment. …

This early-stage trial tests a vaccine called PEP-CMV in 30 children and young adults (ages 3–35) whose medulloblastoma or malignant glioma has come back. The vaccine is designed to train the immune system to attack tumor cells that carry a common virus protein (CMV). Participant…

This early-phase study tests a combination of two drugs—D2C7-IT and atezolizumab—in adults with a recurrent, aggressive type of brain cancer called grade IV malignant glioma. The main goal is to see if the combination is safe and what side effects it may cause. About 18 participa…

This early-phase trial is testing the immunotherapy drug nivolumab in children and young adults whose high-grade glioma has come back or is getting worse. Participants receive the drug before and after surgery to remove as much of the tumor as possible. The main goals are to chec…

This study tests the Optune device, a wearable cap that creates low-intensity electric fields to disrupt cancer cell growth, in children with aggressive brain tumors. One group of children with recurrent high-grade glioma or ependymoma will use the device alone to see if it's fea…

This phase 2 trial tests whether two targeted drugs, dabrafenib and trametinib, can improve outcomes for children and young adults with a specific type of high-grade glioma (BRAF V600-mutant) after they receive radiation therapy. The study enrolls 58 participants aged 25 or young…

This early-stage trial is testing the safety and potential benefit of pembrolizumab, an immunotherapy drug, in 71 children whose brain tumors (like DIPG, high-grade gliomas, or medulloblastoma) have come back or not responded to standard treatments. The drug works by helping the …

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This early-phase study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a type of brain tumor called glioma that has an IDH mutation. The goal is to find the safest dose and see how well the combination works for both newly diagn…

This early-phase trial tests a new immune cell therapy for people with recurrent or treatment-resistant malignant glioma, a type of brain cancer. The treatment uses the patient's own T cells, modified in the lab to recognize and attack cancer cells. The main goal is to find the s…

This study tests if the immunotherapy drug nivolumab can stop or slow the growth of certain brain tumors (gliomas) that have IDH mutations. Researchers are especially interested in tumors with many genetic changes (hypermutator phenotype). The trial involves 62 adults who receive…

This study is testing a new type of MRI scan that looks at sodium and other chemicals in the brain to get a clearer picture of brain tumors (gliomas). The goal is to improve how doctors detect, diagnose, and track these tumors. The study includes healthy volunteers and people wit…

This study tests an online mind-body program designed for people with brain tumors (glioma) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life for both. Researchers are enrolling 74 couples to see if the program is pract…

This study screens children and teens with advanced solid tumors, lymphomas, or histiocytic disorders to find genetic changes in their cancer cells. Participants undergo biopsies and scans to identify mutations that can be targeted by specific drugs. The goal is to see if matchin…

This study tracks a substance called 2-HG in the brains of people with a type of brain cancer (glioma) that has specific gene changes. By using special MRI scans over time, researchers hope to learn how and when these tumors become more aggressive. About 42 adults will have regul…

This study looks at whether adding a special PET scan (18F-DOPA) to the standard MRI can help doctors better plan radiation treatment for people with certain brain tumors (malignant glioma). The PET scan may show tumor tissue more clearly than MRI alone. About 25 participants age…