MALIGNANT GLIOMA

This trial is testing a wearable medical device called Optune for children with aggressive brain tumors. The device uses low-intensity electric fields to try to slow or stop tumor growth. The study has two parts: one for kids whose tumors have come back, and another for kids newl…

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This early-stage trial is testing the safety and early effectiveness of a drug called pembrolizumab in children with aggressive brain tumors that have come back or stopped responding to standard treatments. The drug is an immunotherapy, which aims to help the body's own immune sy…

This study is testing whether adding two targeted drugs, dabrafenib and trametinib, after standard radiation therapy works better for children and young adults with a specific type of aggressive brain tumor. The treatment is for patients whose tumors have a particular genetic cha…

This study is testing whether adding immune-boosting drugs (nivolumab and ipilimumab) to standard chemotherapy can help people with newly diagnosed glioblastoma, a very aggressive brain cancer. Researchers will track 47 adults who have already had surgery and initial treatment, l…

This study is testing a personalized approach for children and young adults with advanced cancers that have come back or stopped responding to standard treatments. Doctors first test the genetic makeup of a patient's tumor to look for specific changes. If a matching change is fou…

This early-phase study is testing the safety and best dose of a personalized immune cell therapy for adults with recurrent or treatment-resistant malignant brain tumors (glioma). Doctors collect a patient's own immune cells, genetically modify them in a lab to recognize and attac…

This early-stage study is testing a new two-drug combination (BGB-290 and temozolomide) for adolescents and young adults with specific types of brain tumors that have returned or are newly diagnosed. The main goal is to find the safest dose and understand the side effects. Resear…

This study is testing whether adding a new drug called veliparib to the standard treatment of radiation and chemotherapy can better control aggressive brain tumors in children and young adults. The trial is for patients aged 3-25 with newly diagnosed high-grade gliomas who have s…

This study is testing a new, experimental type of MRI scan designed to see brain tumors (gliomas) in more detail. The goal is to see if this scan can provide better information about the tumor's biology and how it might respond to treatment. The study involves people with brain t…

This study is testing if a special type of PET scan (using a tracer called 18F-DOPA) can help doctors more accurately plan radiation treatment for malignant brain tumors. It will compare the radiation target areas identified by this new scan with those from the standard MRI scan.…

This study is testing an online meditation and breathing program designed for couples where one person has a brain tumor. The goal is to see if the program is practical and helps improve spiritual well-being, sleep, mood, and overall quality of life for both the patient and their…

This study aims to understand how certain brain tumors change and become more aggressive over time. Researchers will use special brain scans to track chemical levels in the tumors of adults with specific genetic mutations. The goal is to learn if these chemical changes can signal…