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New hope for kids with tough brain tumors: targeted drug shows promise

NCT ID NCT01089101

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink tumors or stop them from growing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) childhood pilocytic astrocytoma low grade glioma neurofibromatosis type 1 optic pathway glioma pilocytic astrocytoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW GRADE GLIOMA RECURRENT CHILDHOOD PILOCYTIC ASTROCYTOMA RECURRENT NEUROFIBROMATOSIS TYPE 1 RECURRENT VISUAL PATHWAY GLIOMA REFRACTORY NEUROFIBROMATOSIS TYPE 1 REFRACTORY VISUAL PATHWAY GLIOMA

Contacts and locations

Locations

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's Memorial Outpatient Center in Lincoln Park

    Chicago, Illinois, 60614, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California, 94304, United States

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois, 60611, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

  • UCSF Medical Center-Mount Zion

    San Francisco, California, 94115, United States

  • UCSF Medical Center-Parnassus

    San Francisco, California, 94143, United States

More trials for these conditions

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