New drug cocktail aims to outsmart childhood brain tumors

NCT ID NCT06712875

Recruiting now Disease control Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This pilot study tests whether combining targeted therapy (MAPK inhibitors like trametinib and dabrafenib) with an immunotherapy drug (nivolumab) can safely and effectively treat children with BRAF-altered gliomas, a type of brain tumor. The study includes children with low-grade or high-grade gliomas that have returned or are hard to treat. The goal is to see if this combination can improve tumor control and reduce the chance of tumor regrowth after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trametinib, dabrafenib, and nivolumab
What this could lead to: If successful, this combination could offer a new treatment option for children with BRAF-altered gliomas that are hard to treat, potentially improving tumor control and survival.
What could go wrong: This is an early-phase pilot study with a small number of participants. The combination may cause significant side effects, and it is unknown if it will work better than current therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

childhood low-grade glioma glioma low grade glioma malignant glioma pediatric high-grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE GLIOMA LOW GRADE GLIOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Children's National Hospital
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20010, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITING

New York, New York, 10065, United States

Contact Email: •••••@•••••

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