Can we stop these cancer drugs without the tumor coming back?

NCT ID NCT07110246

Recruiting now Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 5 times

Summary

This study looks at whether patients with a certain type of slow-growing brain tumor (low-grade glioma with a BRAF V600 mutation) can safely stop or reduce their dose of two targeted drugs, dabrafenib and trametinib, after 12-24 months of treatment. About 96 participants will either stop the drugs abruptly or slowly wean off over 6 months. The goal is to see if the tumor stays under control without the full dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dabrafenib and trametinib
What this could lead to: If successful, this could help doctors find the best way to reduce or stop these drugs without causing the tumor to grow back quickly, improving quality of life for patients.
What could go wrong: This is a small, early-phase trial with only 96 participants, so results may not apply to everyone. There is a risk that stopping or reducing the drugs could cause the tumor to regrow.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

low grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAF V600 MUTATION LOW GRADE GLIOMA LOW GRADE GLIOMA OF BRAIN RECURRENT LOW GRADE GLIOMA

Contacts and locations

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Locations

Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
John Hopkins Medical Center
RECRUITING

Baltimore, Maryland, 21287, United States
Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
St. Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States
St. Louis Children's Hospital Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Email: •••••@•••••
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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