New drug could replace chemo for kids with brain tumor

NCT ID NCT04166409

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 7 times

Summary

This study tests whether a targeted drug called selumetinib works as well as standard chemotherapy (carboplatin and vincristine) for children and young adults with a slow-growing brain tumor called low-grade glioma. Participants must be 2 to 21 years old and have a tumor without certain genetic changes (BRAFV600E or NF1). The goal is to see if selumetinib can control the tumor better and improve quality of life.

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Conditions

The condition(s) this trial relates to.

grade II glioma low grade astrocytic tumor low grade glioma low-grade astrocytoma pilocytic astrocytoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW GRADE ASTROCYTOMA LOW GRADE GLIOMA METASTATIC LOW GRADE ASTROCYTOMA METASTATIC LOW GRADE GLIOMA WHO GRADE 1 GLIOMA WHO GRADE 2 GLIOMA

Contacts and locations

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Locations

AdventHealth Orlando
RECRUITING

Orlando, Florida, 32803, United States
Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202-3591, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
Ascension Saint Vincent Indianapolis Hospital
RECRUITING

Indianapolis, Indiana, 46260, United States

Contact Email: •••••@•••••
BI-LO Charities Children's Cancer Center
RECRUITING

Greenville, South Carolina, 29605, United States
Banner Children's at Desert
RECRUITING

Mesa, Arizona, 85202, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Blank Children's Hospital
RECRUITING

Des Moines, Iowa, 50309, United States
British Columbia Children's Hospital
RECRUITING

Vancouver, British Columbia, V6H 3V4, Canada
C S Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
RECRUITING

Québec, G1V 4G2, Canada
Cardinal Glennon Children's Medical Center
RECRUITING

St Louis, Missouri, 63104, United States
Carilion Children's
RECRUITING

Roanoke, Virginia, 24014, United States
Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Centre Hospitalier Universitaire Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital Medical Center of Akron
RECRUITING

Akron, Ohio, 44308, United States
Children's Hospital New Orleans
RECRUITING

New Orleans, Louisiana, 70118, United States
Children's Hospital and Medical Center of Omaha
RECRUITING

Omaha, Nebraska, 68114, United States
Children's Hospital of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States

Contact Email: •••••@•••••
Children's Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States

Contact Email: •••••@•••••
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Hospital of Pittsburgh of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters
RECRUITING

Norfolk, Virginia, 23507, United States

Contact Email: •••••@•••••
Children's Hospital of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States

Contact Email: •••••@•••••
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

Contact Email: •••••@•••••
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106, United States
Cook Children's Medical Center
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
Corewell Health Children's
ACTIVE_NOT_RECRUITING

Royal Oak, Michigan, 48073, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Covenant Children's Hospital
RECRUITING

Lubbock, Texas, 79410, United States
Dana-Farber Cancer Institute
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Dayton Children's Hospital
RECRUITING

Dayton, Ohio, 45404, United States
Dell Children's Medical Center of Central Texas
RECRUITING

Austin, Texas, 78723, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
East Tennessee Childrens Hospital
RECRUITING

Knoxville, Tennessee, 37916, United States
Eastern Maine Medical Center
RECRUITING

Bangor, Maine, 04401, United States
El Paso Children's Hospital
RECRUITING

El Paso, Texas, 79905, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Golisano Children's Hospital of Southwest Florida
RECRUITING

Fort Myers, Florida, 33908, United States
HIMA San Pablo Oncologic Hospital
ACTIVE_NOT_RECRUITING

Caguas, 00726, Puerto Rico
IWK Health Centre
RECRUITING

Halifax, Nova Scotia, B3K 6R8, Canada

Contact Email: •••••@•••••
Janeway Child Health Centre
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kaiser Permanente-Oakland
RECRUITING

Oakland, California, 94611, United States
Kapiolani Medical Center for Women and Children
RECRUITING

Honolulu, Hawaii, 96826, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

Contact Email: •••••@•••••
Loma Linda University Medical Center
RECRUITING

Loma Linda, California, 92354, United States
Lucile Packard Children's Hospital Stanford University
RECRUITING

Palo Alto, California, 94304, United States
Lurie Children's Hospital-Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Madigan Army Medical Center
RECRUITING

Tacoma, Washington, 98431, United States
Maine Children's Cancer Program
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Mary Bridge Children's Hospital and Health Center
RECRUITING

Tacoma, Washington, 98405, United States

Contact Email: •••••@•••••
Massachusetts General Hospital Cancer Center
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02114, United States
Mattel Children's Hospital UCLA
RECRUITING

Los Angeles, California, 90095, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Methodist Children's Hospital of South Texas
RECRUITING

San Antonio, Texas, 78229, United States
Miller Children's and Women's Hospital Long Beach
RECRUITING

Long Beach, California, 90806, United States
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States

Contact Email: •••••@•••••
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Nemours Children's Clinic - Pensacola
RECRUITING

Pensacola, Florida, 32504, United States

Contact Email: •••••@•••••
Nemours Children's Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital
RECRUITING

Orlando, Florida, 32827, United States
New York Medical College
RECRUITING

Valhalla, New York, 10595, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

Contact Email: •••••@•••••
OSF Children's Hospital of Illinois
RECRUITING

Peoria, Illinois, 61637, United States

Contact Email: •••••@•••••
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Penn State Children's Hospital
RECRUITING

Hershey, Pennsylvania, 17033, United States
Phoenix Childrens Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Prisma Health Richland Hospital
RECRUITING

Columbia, South Carolina, 29203, United States
Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING

Spokane, Washington, 99204, United States
Rady Children's Hospital - San Diego
RECRUITING

San Diego, California, 92123, United States
Rainbow Babies and Childrens Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
Rhode Island Hospital
SUSPENDED

Providence, Rhode Island, 02903, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46202, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Sacred Heart Hospital
SUSPENDED

Pensacola, Florida, 32504, United States
Saint Christopher's Hospital for Children
RECRUITING

Philadelphia, Pennsylvania, 19134, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
RECRUITING

Tampa, Florida, 33607, United States
Saint Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
The Montreal Children's Hospital of the MUHC
RECRUITING

Montreal, Quebec, H3H 1P3, Canada

Contact Email: •••••@•••••
The Steven and Alexandra Cohen Children's Medical Center of New York
RECRUITING

New Hyde Park, New York, 11040, United States
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States

Contact Email: •••••@•••••
UF Health Cancer Institute - Gainesville
ACTIVE_NOT_RECRUITING

Gainesville, Florida, 32610, United States
UMC Cancer Center / UMC Health System
RECRUITING

Lubbock, Texas, 79415, United States
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
WITHDRAWN

Miami, Florida, 33136, United States
University of Minnesota/Masonic Cancer Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
ACTIVE_NOT_RECRUITING

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Walter Reed National Military Medical Center
RECRUITING

Bethesda, Maryland, 20889-5600, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

Contact Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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