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New drug combo targets recurrent brain tumors in kids

NCT ID NCT04485559

Recruiting now Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after previous treatment. The study aims to find the highest dose that is safe and to see how the body processes the drugs. About 50 participants with low-grade or high-grade gliomas will take part.

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Conditions

The condition(s) this trial relates to.

glioma grade II glioma low grade glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE GLIOMA LOW GRADE GLIOMA RECURRENT WORLD HEALTH ORGANIZATION (WHO) GRADE II GLIOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55404, United States

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Dana Farber Cancer Institute

    WITHDRAWN

    Boston, Massachusetts, 02215, United States

  • Doernbecher Children's Hospital Oregon Health & Science University

    ACTIVE_NOT_RECRUITING

    Portland, Oregon, 97239, United States

  • John Hopkins University

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • New York University

    RECRUITING

    New York, New York, 10016, United States

  • Riley Hospital for Children

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • University Of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75235, United States

  • University of Alabama at Birmingham, Children's of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of California, San Diego Rady Children's Hospital

    RECRUITING

    San Diego, California, 92123, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

    Contact Email: •••••@•••••

  • University of Florida

    RECRUITING

    Gainesville, Florida, 32610-0265, United States

  • Washington University in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.