New drug combo targets recurrent brain tumors in kids
NCT ID NCT04485559
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 23 times
Summary
This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after previous treatment. The study aims to find the highest dose that is safe and to see how the body handles the drugs. About 50 participants will be enrolled.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Minnesota
Minneapolis, Minnesota, 55404, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Doernbecher Children's Hospital Oregon Health & Science University
Portland, Oregon, 97239, United States
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John Hopkins University
Baltimore, Maryland, 21287, United States
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Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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New York University
New York, New York, 10016, United States
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Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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University Of Texas Southwestern Medical Center
Dallas, Texas, 75235, United States
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University of Alabama at Birmingham, Children's of Alabama
Birmingham, Alabama, 35233, United States
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University of California, San Diego Rady Children's Hospital
San Diego, California, 92123, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Florida
Gainesville, Florida, 32610-0265, United States
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Washington University in St. Louis
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.