New hope for kids with rare brain tumors? early trial launches in japan

NCT ID NCT07441707

Recruiting now Disease control Sponsor: Ipsen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This early-phase study is testing the safety and how the body handles a drug called tovorafenib in Japanese children, teens, and young adults with a type of brain tumor (low-grade glioma) that has a specific genetic change (BRAF alteration) and has come back or is growing. Six participants will take the drug once a week for up to 24 months, with regular check-ups and scans to see if the tumor shrinks. The study is small and focused on safety, so it's a first step toward possibly finding a new treatment for this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tovorafenib (also known as Ojemda®), a drug taken by mouth once a week
What this could lead to: If it works, this could point toward a treatment option for Japanese children with a specific type of brain tumor that has come back or is getting worse.
What could go wrong: This is a very early, small Phase 1 trial with only 6 participants, so results may not apply broadly. The main goal is safety, not effectiveness, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse low-grade glioma, MAPK pathway–altered low grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW GRADE GLIOMA

Contacts and locations

Locations

Hyogo Prefectural Kobe Children's Hospital
RECRUITING

Kobe, Japan
Kanagawa Children's Medical Center
NOT_YET_RECRUITING

Kanagawa, Japan
Kyoto University Hospital
RECRUITING

Kyoto, Japan
National Cancer Center Hospital
RECRUITING

Tokyo, Japan
National Center for Child Health and Development
RECRUITING

Tokyo, Japan
Osaka City General Hospital
RECRUITING

Osaka, Japan

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