Could a simple blood test spare thyroid cancer patients from unnecessary radiation?

NCT ID NCT04290663

Recruiting now Disease control Sponsor: Centre Francois Baclesse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two approaches for treating intermediate-risk thyroid cancer after surgery. One group gets radioactive iodine as a standard precaution. The other group only gets it if a blood test and scan show signs of remaining cancer. The goal is to see if the selective approach works just as well while avoiding unnecessary treatment and side effects. About 368 patients will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

radioactive iodine (I-131)

What this could lead to

If successful, this could spare many patients from unnecessary radioactive iodine treatment and its side effects, while still controlling the cancer effectively.

What could go wrong

This is a phase 3 trial, but it is still ongoing and results are not yet known. The guided approach might miss some cases that need treatment, or the two strategies could prove equally effective, meaning no change in practice.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma thyroid cancer Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTERMEDIATE RISK THYROID CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AP-HP Pitié Salpétrière
RECRUITING

Paris, France

Contact
Bergonié
RECRUITING

Bordeaux, France

Contact
CHU Pointe à pitre
NOT_YET_RECRUITING

Pointe à Pitre, Guadeloupe, France

Contact
CHU TOULOUSE, Hôpital Larrey
RECRUITING

Toulouse, France

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CHU Timone
RECRUITING

Marseille, France

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Centre Antoine Lacassagne -
RECRUITING

Nice, France

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Centre Francois Baclesse
RECRUITING

Caen, France

Contact Phone: •••-•••-•••• Email: •••••@•••••
Centre Georges-François Leclerc
RECRUITING

Dijon, France

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Centre Henri Becquerel
RECRUITING

Rouen, France

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Centre Hospitalier Métropôle Savoie
RECRUITING

Chambéry, France

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Centre Jean Godinot
RECRUITING

Reims, France

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Centre Jean Perrin
RECRUITING

Clermont-Ferrand, France

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Centre Léon Bérard
RECRUITING

Lyon, France

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Centre Paul Strauss
RECRUITING

Strasbourg, France

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Chru Lille
RECRUITING

Lille, France

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Chu Angers
RECRUITING

Angers, France

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Chu Brest
RECRUITING

Brest, France

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Chu Grenoble
RECRUITING

Grenoble, France

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Chu Martinique
RECRUITING

Fort de France, France

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Chu Nancy
RECRUITING

Nancy, France

Contact Email: •••••@•••••
Chu Nantes
RECRUITING

Nantes, France

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Chu Nimes
RECRUITING

Nîmes, France

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Hospices Civils de Lyon
RECRUITING

Lyon, France

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Hôpital saint-André
RECRUITING

Bordeaux, France

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IUCT Oncopole
RECRUITING

Toulouse, France

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Institu de Cancérologie de l'Ouest - Site Angers
RECRUITING

Angers, France

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Institu de Cancérologie de l'Ouest - Site St Herblain
RECRUITING

Saint-Herblain, France

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Institut CURIE, site Réné Huguenin
RECRUITING

Saint-Cloud, France

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Institut Gustave Roussy
RECRUITING

Villejuif, France

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