DIFFERENTIATED THYROID CANCER

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This study compares two approaches for treating intermediate-risk thyroid cancer after surgery. One group gets radioactive iodine as a standard precaution. The other group only gets it if a blood test and scan show signs of remaining cancer. The goal is to see if the selective ap…

This phase 2 trial tests the drug zanzalintinib given before surgery in 45 people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors, making surgery more effective. Researchers will also monitor safety and side effects.

This phase 2 trial is testing whether giving the drug pembrolizumab before thyroid surgery can help the immune system attack high-risk differentiated thyroid cancer. About 25 adults with a high chance of cancer returning will receive two doses of pembrolizumab before their thyroi…

This study tests whether giving the targeted drug selpercatinib for 6 months before standard radioactive iodine therapy can improve outcomes for children, adolescents, and young adults (ages 2-25) with a specific type of thyroid cancer linked to RET gene fusions. The goal is to s…

This study compares two surgical options for people with low-risk differentiated thyroid cancer: removing only part of the thyroid (hemithyroidectomy) or the entire gland (total thyroidectomy). The goal is to see if the less extensive surgery is as effective at preventing cancer …

This study looks at whether adding radiation therapy to the usual radioactive iodine treatment can help prevent thyroid cancer from coming back in people with high-risk, advanced thyroid cancer. About 124 adults who had surgery but still have some cancer left will be randomly ass…

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer tumors absorb more RAI, potentially improving treatment. It includes 32 children and teens with metastatic differentiated thyroid cancer that has spread to the lungs. Researcher…

This phase 2 trial tests whether giving larotrectinib for 6 months can make thyroid cancer cells more responsive to radioactive iodine therapy. It enrolls 13 children and young adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is t…

This study compares a newer type of scan (I-124 PET/CT) to the standard scan (I-123 whole body imaging) for finding thyroid cancer that has spread. About 62 people with thyroid cancer will get both scans, and researchers will see if the new scan is more accurate. The goal is to i…

This study tests whether a special PET scan using a radioactive tracer called 68Gallium-DOTATATE can better detect thyroid cancer that has spread and no longer responds to standard radioactive iodine therapy. About 54 adults with metastatic thyroid cancer will receive one injecti…

This study tests a new imaging agent called F-18 TFB for PET/CT scans in people who have had surgery and radioactive iodine for differentiated thyroid cancer but still have high tumor markers. The goal is to see if F-18 TFB finds cancer lesions better than the standard FDG PET/CT…

This study tests a website designed to help thyroid cancer patients manage symptoms after radioactive iodine (RAI) treatment. About 88 adults who had RAI in the last three years will use either the new website or a standard one for four weeks. Researchers will check if the tool i…

This study tests a decision support tool that uses blood samples from the first two weeks after thyroid surgery to predict the best levothyroxine dose. Normally, dose adjustments take months of trial and error. The trial will enroll 240 patients and compare the tool's guidance to…

This study tests two ways of preparing people with advanced thyroid cancer for a special PET scan that uses a radioactive form of iodine (I-124). The goal is to see which preparation method gives better information for calculating the right dose of radiation therapy. Thirty parti…

This study will compare pain levels after three different surgical methods for removing lymph nodes in the neck (lateral neck dissection) in people with thyroid cancer. The three methods are robotic surgery, endoscopic surgery, and traditional open surgery. Researchers will measu…

This study aims to create a simple tool that helps doctors predict how difficult a specific type of thyroid cancer surgery (called transoral and submental thyroidectomy) will be. Researchers will study 500 patients to find out which factors before surgery make the operation harde…

This study aims to improve a prediction model that helps doctors know how difficult a less invasive thyroid surgery might be. Researchers will observe 300 people with thyroid cancer or benign nodules to see which factors, like age, weight, and tumor size, affect surgery difficult…

This study aims to create and test a scoring system called RTAS to evaluate how well surgeons perform robotic thyroidectomy, a surgery to remove all or part of the thyroid gland. Researchers will observe 200 participants with thyroid cancer or benign nodules who are having this s…

This study follows children who had radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will compare them to children who did not have radiation, looking for risk factors and genetic clues. The goal is to create better screeni…

This study looks at how a 7-day low-iodine diet changes the amount of radioactive iodine taken up by the body in people who have had their thyroid removed due to thyroid cancer. Researchers will measure iodine uptake before and after the diet in 25 adults. The goal is to understa…

This study tests a special collar worn around the neck that measures radiation exposure in people with thyroid cancer or Graves' disease receiving radioactive iodine therapy. The goal is to see if this device gives more accurate dosing information than current methods, potentiall…