Can we make CAR-T cells last longer in leukemia?
NCT ID NCT05809284
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study follows children and young adults with acute lymphoblastic leukemia (ALL) who receive CAR-T cell therapy. The goal is to track how long these engineered immune cells persist in the body and identify factors that cause them to disappear. By understanding why CAR-T cells fade, researchers hope to improve the durability of this treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CD19-targeted CAR-T cell therapy (tisagenlecleucel)
- What this could lead to
- If successful, this could reveal why CAR-T cells stop working in some patients, potentially leading to longer-lasting remissions or improved treatments for ALL.
- What could go wrong
- This is an observational study, so it won't test a new treatment. It may not identify all factors affecting CAR-T persistence, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Great Ormond Street Hospital
RECRUITINGLondon, United Kingdom
-
Royal Manchester Children's Hospital
RECRUITINGManchester, United Kingdom
-
University College London Hospital
RECRUITINGLondon, United Kingdom
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