University College, London

This study looks at people who have chest X-ray signs of TB but whose sputum tests are negative. It tests whether shorter treatment (8 to 24 weeks) works as well as the standard 24-week course. 784 participants will be randomly assigned to different treatment lengths or close mon…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover better after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months. The goal is to see if these me…

Trigeminal neuralgia causes sudden, severe electric-shock-like pain in the face, often mistaken for a tooth problem. This observational study tests a 15-item questionnaire (IDTN) to see if it can accurately identify possible trigeminal neuralgia in patients visiting dental clinic…

This study compares an AI algorithm to radiologists in reading prostate MRI scans to detect clinically significant prostate cancer. About 500 men with suspected prostate cancer will have their MRI read by both AI and a radiologist, and results will be compared. If the AI performs…

This study explores whether foot pressure patterns, measured while standing and walking, can be used with machine learning to detect adolescent idiopathic scoliosis early. Researchers will collect data from 500 teens aged 10-18, including those with and without scoliosis. The goa…

This study tests whether trained young mentor mothers (YMMs) can help pregnant and breastfeeding teenage girls and young women (ages 15-24) in Zimbabwe use HIV prevention tools like PrEP and contraception. About 600 participants will be assigned to either receive support from YMM…

This study tests whether an intensive, personalized speech therapy program (ICAP) can improve communication and quality of life for people with aphasia after a stroke. Researchers will compare ICAP (100 hours over 4 weeks) to standard NHS care in 334 adults who are at least 3 mon…

This study tests a headband-like device called Nettle that delivers gentle electrical stimulation to parts of the brain involved in pain. Twenty adults with chronic migraine will use it at home for 20 minutes each day over three months. The main goal is to see if people can stick…

This study tests a new device called RespiraFibre, a tiny sensor that attaches to oxygen masks or tubes to continuously measure breathing rate. Breathing rate is one of the best early signs that a patient is getting worse, but current methods are often inaccurate or skipped. The …

This study will enroll 50 adults with a detached retina to analyze their eye fluid and take detailed images before and after surgery. The goal is to find markers that could predict a complication called proliferative vitreoretinopathy (PVR), which can cause vision loss. Participa…

This study tests whether a new online tool, called BeSpoke, helps men with newly diagnosed localized prostate cancer make better treatment decisions. The tool gives personalized information about different treatments and their likely outcomes. Researchers will compare men who use…

This study looks at whether people who had a stroke more than six months ago and cannot move their fingers can regain that ability. Researchers will use brain stimulation and nerve tests to understand who might benefit. Participants will receive electrical muscle stimulation and …

This study tests whether adding a small step—cauterizing tiny blood vessels—during standard burr-hole surgery for chronic subdural hematoma (a common brain bleed in older adults) is safe and doable. About 30 adults will take part, and no extra scans or radiation are needed. The g…

This study tests whether adding social prescribing—connecting young people to community activities like arts, sports, or volunteering—can improve mental health for teens already in therapy. 120 participants aged 11-18 with emotional difficulties will be randomly assigned to eithe…

This study tests whether artificial intelligence can help surgical teams during pituitary tumor surgery performed through the nose. The AI watches live video of the surgery to identify anatomy and instruments, then shows its analysis on tablets for residents and nurses—not the le…