Scientists map hidden nerve wires to make epilepsy treatment safer

NCT ID NCT05664854

Recruiting now Knowledge-focused Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to create a detailed map of the vagus nerve's internal wiring during routine epilepsy surgery. Researchers will use special electrode cuffs to stimulate different parts of the nerve and record which organs respond, while also taking quick electrical images. The goal is to understand how to stimulate only the right nerve bundles to treat epilepsy without causing side effects like voice changes or heart problems. Fifty adults already scheduled for vagus nerve stimulator implantation will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nerve cuff electrodes for stimulation and imaging
What this could lead to: If successful, this could lead to more precise vagus nerve stimulation with fewer side effects for conditions like epilepsy.
What could go wrong: This is a very early, small study (50 people) focused on mapping, not treatment. It may not lead to better devices or outcomes.

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Conditions

The condition(s) this trial relates to.

epilepsy vagus nerve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY VAGUS NERVE AUTONOMIC DISORDER VAGUS NERVE DISEASES

Contacts and locations

Locations

National Hospital of Neurology and Neurosurgery
RECRUITING

London, Greater London, WC1N 3BG, United Kingdom

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