Scientists probe why exercise lifts mood in depression

NCT ID NCT06387732

Recruiting now Knowledge-focused Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study aims to uncover why physical activity reduces depression symptoms. Researchers will compare aerobic exercise with stretching in 250 adults with moderate depression, measuring changes in brain activity, immune markers, and motivation. The goal is to understand the underlying mechanisms so exercise programs can be made more effective and personalized.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aerobic exercise
What this could lead to: If successful, this could help design more effective, personalized exercise programs for depression and guide social prescribing in mental healthcare.
What could go wrong: This is an early-stage mechanistic study, not a treatment trial. Results may not lead to direct clinical changes, and the control group also receives an active intervention (stretching), which may limit differences.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DEPRESSION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Depression depressive disorder Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Institute of Cognitive Neuroscience, University College London
RECRUITING

London, WC1N 3AZ, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.