New hope for older lymphoma patients: gentler drug combo shows promise

NCT ID NCT05004064

Ongoing Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing a combination of two drugs, acalabrutinib and rituximab, in elderly or frail patients who have not yet been treated for mantle cell lymphoma. The goal is to see how well the drugs shrink or control the cancer. The study involves 48 participants aged 60 and older who are not fit for standard chemotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acalabrutinib and rituximab
What this could lead to: If successful, this combination could offer a gentler, effective treatment option for older or frail patients with mantle cell lymphoma who cannot tolerate standard chemotherapy.
What could go wrong: This is a small, early-phase (phase 2) study with only 48 participants and no comparison group, so results may not apply broadly. Side effects from the drugs are possible, and the treatment is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mantle cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MANTLE CELL LYMPHOMA

Contacts and locations

Locations

Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom
Cancer and Haematology Centre, Churchill Hospital

Oxford, United Kingdom
Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, United Kingdom
Derriford Hospital

Plymouth, United Kingdom
Norfolk and Norwich University Hospital

Norwich, United Kingdom
Royal Cornwall Hospital

Truro, United Kingdom
Royal Stoke Hospital

Stoke-on-Trent, United Kingdom
St. Bartholomew's Hospital

London, United Kingdom
The Christie Hospital

Manchester, United Kingdom
The Royal Bournemouth Hospital

Bournemouth, United Kingdom
University College London Hospital

London, United Kingdom
University Hospital of Wales

Cardiff, United Kingdom

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