New absorbable beads aim to plug anal fistulas without major surgery
NCT ID NCT03707769
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This first-in-human study tested whether TIPS microspheres—tiny absorbable beads—can safely help heal perianal fistulas (abnormal tunnels near the anus). Thirteen adults with simple fistulas received the beads during a standard procedure. The main goal was to check safety, with early signs of healing also tracked. Because it's a small, early study, results are preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TIPS microspheres (a bioabsorbable device made from PLGA, used as a paste)
What this could lead to
If it works, this could offer a new, safer way to help heal perianal fistulas without major surgery.
What could go wrong
This is a very early, small study (13 people) with no control group. The main goal is safety, not proof of effectiveness. Risks include infection, abscess, or need for further surgery.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University College London Hospitals
London, United Kingdom