New absorbable beads aim to plug anal fistulas without major surgery

NCT ID NCT03707769

Completed Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This first-in-human study tested whether TIPS microspheres—tiny absorbable beads—can safely help heal perianal fistulas (abnormal tunnels near the anus). Thirteen adults with simple fistulas received the beads during a standard procedure. The main goal was to check safety, with early signs of healing also tracked. Because it's a small, early study, results are preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TIPS microspheres (a bioabsorbable device made from PLGA, used as a paste)
What this could lead to: If it works, this could offer a new, safer way to help heal perianal fistulas without major surgery.
What could go wrong: This is a very early, small study (13 people) with no control group. The main goal is safety, not proof of effectiveness. Risks include infection, abscess, or need for further surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anal fistula

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIANAL FISTULA

Contacts and locations

Locations

University College London Hospitals

London, United Kingdom

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