Systolic heart failure

This study is a large registry that will follow 5,000 people with heart failure who have received a Barostim implant. The goal is to see how well the device works in everyday medical practice to improve symptoms and quality of life. Participants are already implanted and will be …

This trial tests whether a single intravenous iron infusion can improve exercise capacity in people with heart failure and iron deficiency. Participants are randomly assigned to receive the infusion or no treatment, then undergo cardiopulmonary exercise testing to measure peak ox…

This trial tests whether intravenous (IV) iron or oral iron pills work better for adults with congestive heart failure who also have low iron levels. Participants are randomly assigned to receive either a one-time IV infusion of ferric carboxymaltose (with a possible repeat dose)…

This study tested whether a wearable device and digital care plan from the American Heart Association could help people with systolic heart failure. Participants wore the device for 90 days while their care team monitored their data. The trial was terminated early and only enroll…

This study tested an experimental drug called XXB750 in 136 people with heart failure. The goal was to see if it could improve heart function and symptoms. The trial was terminated early, so the full results are not available.

This study tested a single dose of an experimental antibody called REGN5381 in 89 people with chronic heart failure and reduced pumping ability. The goal was to check safety, how the drug moves in the body, and its effects on heart stress markers. The trial was terminated early, …

This early-stage trial tested an experimental drug called AZD3427 in 10 people with heart failure and reduced kidney function. The goal was to see if the drug could improve blood flow to the kidneys, measured with a special PET scan. However, the study was terminated early, so we…

This early study tested a new drug called AZD5462 added to the standard medicine dapagliflozin in people with heart failure and moderate kidney disease. Only 8 participants were enrolled before the study was stopped. The goal was to see if the combination is safe and affects how …

This study looked at whether breathing air with less oxygen (like at high altitude) during exercise training could help people with heart failure do more physical activity. Only 14 patients were enrolled before the study was stopped early. The main goal was to see if this method …

This study tested if a gentle nerve stimulation (like a mild electrical pulse on the neck) could improve blood vessel health and memory in people with heart failure. Only 7 people took part before the study was stopped early. The goal was to see if 4 weeks of stimulation could re…

This study tested whether a special breathing exercise program could help people with systolic heart failure walk farther and feel better. The trial planned to enroll 65 adults with moderate heart failure, but it was terminated early. Participants would have been assigned to eith…

This study looked at whether implantable defibrillators (ICDs) help people with heart failure and a lower risk of deadly heart rhythms live longer compared to not having an ICD. It involved over 3,000 adults with weak heart pumps. The goal was to see if the benefits of ICDs still…