Heart failure drug trial halted early – what we know
NCT ID NCT06237309
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a single dose of an experimental antibody called REGN5381 in 89 people with chronic heart failure and reduced pumping ability. The goal was to check safety, how the drug moves in the body, and its effects on heart stress markers. The trial was terminated early, so final results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
REGN5381 (an experimental antibody given as a single intravenous infusion)
What this could lead to
If successful, this could point toward a new treatment to help manage chronic heart failure by improving heart function.
What could go wrong
This was an early phase 2 trial that was terminated, so results are limited. The drug is still experimental and may not prove safe or effective.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AZ Oostende
Ostend, West Vlaanderen, 8400, Belgium
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Algemeen Ziekenhuis Groeninge
Kortrijk, West Vlaanderen, 8500, Belgium
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Algemeen Ziekenhuis St Jan Brugge Oostende Av
Bruges, West Flanders, 8000, Belgium
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Anima Research Center
Alken, Limburg, 3570, Belgium
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Arensia Exploratory Medicine Clinic
Phoenix, Arizona, 85015, United States
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Arensia Exploratory Medicine Clinic at MBAL Sveta Sofia
Sofia, 1618, Bulgaria
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Arensia Exploratory Medicine Clinic at Monza Bucharest
Bucharest, 11658, Romania
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Arensia Exploratory Medicine at the Research Institute of Clinical Medicine
Tbilisi, 0112, Georgia
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Athens Naval Hospital
Athens, Attikh, 11521, Greece
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Centre Hospitalier Regional de la Citadelle
Liège, 4000, Belgium
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Clinmedica Research sp zo.o.
Skierniewice, Łódź Voivodeship, 96-100, Poland
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Dr M I Sarvan,R Moodley & partners
Durban, KwaZulu-Natal, 4321, South Africa
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Edumed
Jaroměř, 55101, Czechia
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Fakultni Nemocnice v Motole
Prague, Central Bohemian, 15006, Czechia
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First Cardiology Clinic University of Athens
Athens, Attica, 11527, Greece
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Flourish Research - Miami (Kendall) (Formerly Clinical Site Partners)
Miami, Florida, 33186, United States
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Flourish Research - Orlando (Formerly Clinical Site Partners)
Winter Park, Florida, 32789, United States
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General University Hospital Attikon
Chaïdári, 12462, Greece
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Grand Hopital de Charleroi
Gilly, Hainaut, 6060, Belgium
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Harbor UCLA Medical Center
Torrance, California, 90509, United States
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Hospital Arnau de Vilanova
Valencia, 46015, Spain
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Hospital Universitario Virgen Macarena Unidad Coronaria 1 planta
Seville, 41009, Spain
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Hospital Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120, Spain
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Into Research
Groenkloof, Gauteng, 0181, South Africa
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Korea University Guro Hospital
Seoul, 8308, South Korea
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Kuils River Hospital
Kuils River, Western Cape, 7580, South Africa
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Larissa University Hospital
Larissa, 41110, Greece
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MHAT Haskovo
Haskovo, 6300, Bulgaria
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Medical University of Lodz
Lodz, 90-549, Poland
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Medicus Services s.r.o.
Brandýs nad Labem-Stará Boleslav, 25001, Czechia
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NZOZ Gemini
Żychlin, 62-571, Poland
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Onze Lieve Vrouw Ziekenhuis Aalst
Aalst, Oost-Vlaanderen, 9300, Belgium
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Pmsi Republican Clinical Hospital Timofei Mosneaga
Chisinau, MD-2025, Moldova
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Sc Arensia Exploratory Medicine Srl
Cluj-Napoca, 400006, Romania
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Severance Hospital at Yonsei University College of Medicine
Seoul, Seodaemun-gu, 03722, South Korea
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UCK Medical University of Warsaw
Warsaw, Masovian Voivodeship, 02-097, Poland
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UZ Leuven
Leuven, Vlaams Brabant, 3000, Belgium
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University Hospital Brno
Brno, South Moravian, 62500, Czechia
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University Multiprofile Hospital for Active Treatment Plovdiv
Plovdiv, 4000, Bulgaria
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Virgen de las Montañas Hospital
Villamartín, Cadiz, 11650, Spain
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Wojewodzki Szpital Zespolony - Ludwik Rydygier Provincial Hospital
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
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Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426, South Korea
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