MRI scans may predict who benefits from MitraClip heart valve repair

NCT ID NCT07131631

Recruiting now Knowledge-focused Sponsor: Minneapolis Heart Institute Foundation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will use cardiac MRI scans to measure heart muscle scarring in 125 people with heart failure and a leaky mitral valve who are scheduled for a MitraClip procedure. Researchers want to see if the amount of scarring predicts how well the heart recovers six months later. Participants will have an MRI before the procedure and again at six months, along with questionnaires about their symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors predict which patients will benefit most from the MitraClip procedure, leading to better treatment decisions.
What could go wrong: This is an observational study, not a treatment trial. It will not test a new therapy, and results may not change current practice immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure mitral valve insufficiency systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUNCTIONAL MITRAL REGURGITATION HEART FAILURE AND REDUCED EJECTION FRACTION

Contacts and locations

Locations

Cleveland Clinic
ENROLLING_BY_INVITATION

Cleveland, Ohio, 44195, United States
IRCCS Ospedale San Raffaele
ENROLLING_BY_INVITATION

Milan, 20132, Italy
Inova Fairfax Medical Campus
ENROLLING_BY_INVITATION

Falls Church, Virginia, 22042, United States
Minneapolis Heart Institute Foundation
RECRUITING

Minneapolis, Minnesota, 55407, United States
Sanger Heart and Vascular Institute
ENROLLING_BY_INVITATION

Charlotte, North Carolina, 28204, United States
The Christ Hospital Health Network
ENROLLING_BY_INVITATION

Cincinnati, Ohio, 45219, United States

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