New clip device could spare High-Risk heart patients from open surgery
NCT ID NCT03271762
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a device called MitraClip, which repairs the mitral valve through a small tube inserted in a blood vessel, works as well as traditional open-heart surgery for people with severe mitral regurgitation who are at high risk for surgery. About 330 participants will be randomly assigned to get either the MitraClip or surgery and followed for two years. The main goal is to see if the clip is non-inferior in preventing death, heart failure hospitalizations, and repeat valve procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MitraClip device (percutaneous mitral valve repair)
What this could lead to
If successful, this could offer a less invasive alternative to open-heart surgery for people with severe mitral regurgitation who are too frail for surgery.
What could go wrong
This is a non-inferiority trial, meaning it aims to show MitraClip is not worse than surgery, not that it is better. The device may still have risks like bleeding or valve complications, and long-term durability is unknown.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MITRAL REGURGITATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
CHU Félix Guyon
Saint-Denis, 97400, France
-
CHU LYON
Lyon, France
-
CHU de Rouen
Rouen, France
-
Centre Cardiologique Du Nord
Saint-Denis, France
-
Centre Chirurgical Marie Lannelongue
Le Plessis-Robinson, France
-
Ch Annecy
Annecy, 74370, France
-
Chru Brest
Brest, France
-
Chru Lille
Lille, 59000, France
-
Chru Tours
Tours, France
-
Chu Angers
Angers, France
-
Chu Bordeaux
Bordeaux, France
-
Chu Grenoble
Grenoble, France
-
Chu Nantes
Nantes, France
-
Chu Poitiers
Poitiers, France
-
Chu Rennes
Rennes, France
-
Chu Saint Etienne
Saint-Etienne, 42277, France
-
Clinique Du Millenaire
Montpellier, 34000, France
-
Clinique Du Tonkin
Villeurbanne, 69100, France
-
Clinique Pasteur
Toulouse, France
-
Clinique de La Sauvegarde
Lyon, 69009, France
-
Hopital Bichat
Paris, France
-
Hopital Civil Strasbourg
Strasbourg, France
-
Hopital Europeen Georges Pompidou
Paris, France
-
Hopital Henri Mondor Aphp
Créteil, France
-
Hopital La Pitie Salpetriere
Paris, France
-
Hopital La Timone
Marseille, France
-
Hopital Prive Le Bois Lille
Lille, 59000, France
-
Hopital Rangueil
Toulouse, France
-
Hopital St Joseph
Marseille, France
-
Institut Hospitalier Jacques Cartier
Massy, France
-
Institut Mutualiste Montsouris
Paris, France