MITRAL REGURGITATION

This study tests a new device called the Medtronic Intrepid™ system to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve). The device is placed through a tube in the leg, avoiding open-heart surgery. The study will enroll 400 people whose he…

This study tests a new device called the Tioga TMVR System to treat a leaky heart valve (mitral regurgitation) without open-heart surgery. It involves 30 adults with moderate-to-severe symptoms who are not good candidates for surgery. The goal is to see if the device is safe and …

This study is for people with a severely hardened mitral valve (mitral annular calcification) that causes symptoms like shortness of breath and fatigue, but who are too high-risk for open-heart surgery. The trial will test a new way to replace the valve using a thin tube inserted…

This study looks at the best way to use blood thinners after a minimally invasive heart valve repair (TEER) in people with mitral regurgitation who also need long-term anticoagulation. About 880 participants will be randomly assigned to different blood-thinning strategies. The ma…

This study tests a procedure called transcatheter mitral valve repair (TEER) in people with cardiogenic shock (a life-threatening condition where the heart can't pump enough blood) and a leaky mitral valve. About 144 participants will be randomly assigned to either standard medic…

This early study tests a new device called the ReValve System to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve). The goal is to see if the device can be safely delivered and reduce the leak. The study involves 20 people who need mitral v…

This study is testing a new device called the Cephea Mitral Valve System to treat people with mitral valve disease (leaky or narrowed heart valves) who are not good candidates for open-heart surgery. The device is placed using a thin tube through a blood vessel, avoiding major su…

This study tests a hospital-wide treatment plan for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the plan helps doctors identify who will benefit most from a minimally invasive valve repair procedure called MitraClip. …

This study is testing a new device called the HighLife mitral valve for people with a severe leaky heart valve (mitral regurgitation) who are too high-risk for open-heart surgery. The valve is placed through a tube inserted in a vein, avoiding the need for major surgery. The stud…

This study looks at the best way to use blood thinners after a minimally invasive heart valve repair (called TEER) in people with mitral regurgitation, a common heart valve problem. About 1,032 participants who do not need long-term blood thinners will be randomly assigned to dif…

This study tests a new device called GeminiOne that repairs leaky heart valves without open-heart surgery. It is for people with severe mitral regurgitation who are too high-risk for surgery. The goal is to see if the device is safe and effectively reduces the leak, helping patie…

This study tests a new device called the SAPIEN M3 System to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve) who cannot have standard surgery or other treatments. The goal is to see if the device is safe and effective at reducing death an…

This early study tests a new device called the CardioMech Mitral Valve Repair System in 25 people with a leaky mitral heart valve (moderate to severe). Participants are at intermediate or high risk for open-heart surgery. The goal is to see if the device is safe and can reduce th…

This study tests a new device called the Cephea Mitral Valve System for people with a leaky or narrowed heart valve (mitral valve disease). The goal is to see if it is safe and works well for patients who are not good candidates for open-heart surgery. About 50 participants will …

This study is a registry that collects information from 1,000 people with symptomatic mitral valve disease (leaky or narrowed heart valve). The goal is to learn how patients respond to a less-invasive valve replacement procedure called TMVR. This data will help doctors improve tr…

This study is a registry that collects information from 1000 people with a leaky mitral valve (mitral regurgitation) who are being considered for a catheter-based valve replacement. The goal is to see how well different treatments work in real-world settings, including valve repl…

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…

This study looks at 90 people with a heart condition called mitral valve prolapse who need surgery to fix a leaky valve. Researchers want to see if the surgery reduces dangerous heart rhythms and changes scarring in the heart muscle. Participants will have heart scans and wear a …