MITRAL REGURGITATION

This study tests whether a small wireless sensor placed in the pulmonary artery can help doctors better manage medications for people with heart failure and a leaky mitral valve. The sensor constantly measures pressure inside the heart, giving doctors real-time data to adjust tre…

This early-stage study tests a new device called the ReValve system to replace the mitral valve in people with severe valve leakage. About 25 adults with symptoms like shortness of breath will get the device to see if it can be delivered safely and works as intended. The goal is …

This study tests a new device called the SATURN system, which is implanted through a tube in a blood vessel to replace a leaky mitral heart valve. It is for people aged 65 and older with severe symptoms who are not good candidates for open-heart surgery. The goal is to see if the…

This study follows 550 people who receive Abbott annuloplasty rings or bands during surgery to fix leaky mitral or tricuspid heart valves. Researchers will track survival, need for repeat surgery, and symptom improvement for five years. The goal is to confirm the devices work wel…

This study tests a minimally invasive procedure to repair a leaky heart valve in people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 144 adults in intensive care will be randomly assigned to either standard medical therapy or…

This study tests a new device called GeminiOne that repairs a leaky heart valve (mitral regurgitation) without open-heart surgery. It involves 15 adults with severe symptoms who are not good candidates for surgery. The goal is to see if the device is safe and effectively reduces …

This study tests a new device called the Cephea Mitral Valve System for people with a leaky or narrowed mitral heart valve. The goal is to see if it is safe and works well for patients who are not good candidates for open-heart surgery. About 50 people will get the device and be …

This study looks at the best blood-thinning medicine after a minimally invasive heart valve repair for mitral regurgitation, a common heart condition. About 1,032 participants will be randomly assigned to take either aspirin alone or aspirin plus clopidogrel. The goal is to see w…

This study looks at 880 people who had a minimally invasive heart valve repair and also need long-term blood thinners. It compares taking just one blood thinner (rivaroxaban) versus taking two (rivaroxaban plus clopidogrel) to see which causes fewer bleeding problems over one yea…

This early study is testing a new device called the ReValve System to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve). The trial will enroll 20 people who are eligible for mitral valve surgery. The main goal is to see if the device can be…

This study tests a new device called SAPIEN M3 that can replace a leaky mitral heart valve using a thin tube inserted through a vein in the leg. It is for people with severe symptoms who cannot have standard surgery or other less invasive treatments. The goal is to see if the dev…

This early study tests a new device called the CardioMech Mitral Valve Repair System in 25 people with moderate to severe mitral regurgitation (a leaky heart valve) who are at intermediate or high risk for surgery. The device is delivered through a catheter to repair the valve wi…

This study is testing a new device called the Cephea Mitral Valve System for people with mitral valve disease (leaky or narrowed heart valves) who cannot have open-heart surgery. The goal is to see if the device is safe and works well. About 20 people will take part.

This study is testing a new way to replace a damaged heart valve (the mitral valve) without open-heart surgery. It uses a special valve delivered through a thin tube (catheter) for people with severe symptoms who are not healthy enough for standard surgery. The study will enroll …

This study tests a new device (Intrepid TMVR) to replace the mitral valve in people with severe mitral regurgitation (leaky heart valve) who are not candidates for standard surgery or repair. About 400 participants will receive the device and be followed for safety and effectiven…

This study tests a new device called the Tioga TMVR System to treat a leaky heart valve (mitral regurgitation) without open-heart surgery. It will include 30 people with moderate to severe symptoms who are not good candidates for surgery. The main goals are to see if the device i…

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study is testing a new device called the HighLife 28mm mitral valve, which is placed through a tube in a vein to replace a leaky heart valve without open-heart surgery. It is for 120 people with moderate-severe or severe mitral regurgitation who are at high risk for surgery.…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see which measures heart valve disease more accurately. Researchers will enroll 200 adults with suspected moderate or severe valve problems. The goal is to improve how doctors assess va…

This study is a registry that collects information from 1,000 people with symptomatic mitral valve disease, including mitral regurgitation and stenosis. The goal is to better understand how correcting these heart valve problems with a less invasive procedure called transcatheter …

This registry is following 1,000 patients with a leaky mitral valve (mitral regurgitation) who undergo a minimally invasive procedure called transcatheter mitral valve replacement (TMVR). The goal is to see how well the procedure works in everyday medical practice, including how …

This study aims to find biological differences between men and women with heart valve disease using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe aortic or mitral valve problems. The goal is to better predict how the heart recovers after valv…

This study tests a hospital-wide treatment guide for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the guide helps doctors identify which patients will benefit most from a minimally invasive valve repair procedure calle…

This study will follow 90 people with mitral valve prolapse who are already scheduled for mitral valve surgery. Researchers will use heart scans and 7-day rhythm monitors before and 6 months after surgery to see if the procedure reduces dangerous heart rhythms and scarring. The g…