MITRAL REGURGITATION

This early trial tests a new device called Anchord that repairs leaky mitral valves without open-heart surgery. It will include 5 people with severe valve leakage who are too high-risk for standard surgery. The goal is to see if the device is safe and can reduce the leak, improvi…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This early study tests a new device called the SATURN TS TMVR System, which is implanted through a catheter to replace the mitral valve in people with severe mitral regurgitation. Up to 15 patients who are too high-risk for open-heart surgery will be enrolled. The goal is to see …

This study tests whether creating a small opening between the upper heart chambers during mitral valve repair can prevent heart failure symptoms after surgery. Researchers will compare 50 patients who get the extra opening to those who have standard surgery alone. The goal is to …

This registry follows 1,000 adults with mitral regurgitation who receive the MitraClip G5, a device that repairs the heart valve without open-heart surgery. Researchers will measure how well the procedure reduces valve leakage and improves symptoms like shortness of breath. All d…

This early study tests a device called the MRace implant to treat moderate-to-severe mitral regurgitation, a condition where the heart valve leaks. About 15 people will get the implant and be followed for up to 5 years to see if it safely reduces the leak and improves symptoms. T…

This registry will follow 150 people with severe mitral regurgitation who receive the HighLife transcatheter mitral valve replacement system. The goal is to see how well the device works and how safe it is when used in everyday medical practice. Participants are treated according…

This study will enroll 404 people with severe leakage in both the mitral and tricuspid heart valves. Participants will be randomly assigned to have either both valves repaired at once using a catheter-based device, or only the mitral valve repaired. The goal is to see which appro…

This study tests a new heart valve (SAPIEN X4) in 125 people with mitral valve disease who are too high-risk for open-heart surgery. The valve is placed using a thin tube through a blood vessel, avoiding major surgery. The goal is to see if the valve is safe and improves heart fu…

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study will implant a small heart monitor under the skin of 100 people with moderate-to-severe mitral valve regurgitation who have few or no symptoms. The device will track heart rhythms for up to three years to find hidden atrial fibrillation that standard tests might miss. …

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …

This study looks at 300 people with severe mitral regurgitation who need heart surgery. Researchers want to see if a special ultrasound technique called speckle tracking can better predict who will do well after surgery, compared to the current standard method. The study only use…