Poop pills may stop gut Flare-Ups after colitis surgery

NCT ID NCT03524352

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a fecal microbiota transplant (FMT) from a healthy donor can delay or prevent pouchitis, a common complication after ulcerative colitis patients have their colon removed and a pouch created. About 42 adults who have had this surgery and have had pouchitis before will receive either FMT or a placebo. Researchers will track how long it takes for pouchitis to return.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

fecal microbiota transplant (FMT)

What this could lead to

If it works, this could provide a new way to prevent pouchitis flare-ups in people with ulcerative colitis who have had pouch surgery.

What could go wrong

This is a small, early-phase trial with only 42 participants, so results may not apply to everyone. FMT also carries risks like infection or digestive upset.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

pouchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHRU Nancy

    Nancy, France

  • CHU Angers

    Angers, France

  • CHU Claude Huriez

    Lille, France

  • CHU Estaing

    Clermont-Ferrand, France

  • CHU Henry Mondor

    Créteil, France

  • CHU Lyon Sud

    Lyon, France

  • CHU Pontchaillou

    Rennes, France

  • CHU Toulouse

    Toulouse, France

  • CHU de l'Archet 2

    Nice, France

  • CHU of Nantes

    Nantes, France

  • Groupe Hospitalier Sud- Hopital Haut-lévêque

    Pessac, France

  • Hopital Beaujon, Clichy

    Clichy, France

  • Hopital Saint Antoine

    Paris, France