Poop pills may stop gut Flare-Ups after colitis surgery

NCT ID NCT03524352

Ongoing Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a fecal microbiota transplant (FMT) from a healthy donor can delay or prevent pouchitis, a common complication after ulcerative colitis patients have their colon removed and a pouch created. About 42 adults who have had this surgery and have had pouchitis before will receive either FMT or a placebo. Researchers will track how long it takes for pouchitis to return.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fecal microbiota transplant (FMT)
What this could lead to: If it works, this could provide a new way to prevent pouchitis flare-ups in people with ulcerative colitis who have had pouch surgery.
What could go wrong: This is a small, early-phase trial with only 42 participants, so results may not apply to everyone. FMT also carries risks like infection or digestive upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pouchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POUCHITIS

Contacts and locations

Locations

CHRU Nancy

Nancy, France
CHU Angers

Angers, France
CHU Claude Huriez

Lille, France
CHU Estaing

Clermont-Ferrand, France
CHU Henry Mondor

Créteil, France
CHU Lyon Sud

Lyon, France
CHU Pontchaillou

Rennes, France
CHU Toulouse

Toulouse, France
CHU de l'Archet 2

Nice, France
CHU of Nantes

Nantes, France
Groupe Hospitalier Sud- Hopital Haut-lévêque

Pessac, France
Hopital Beaujon, Clichy

Clichy, France
Hopital Saint Antoine

Paris, France

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