Can parathyroid surgery protect the heart and kidneys? new study follows 403 patients for 5 years

NCT ID NCT05469087

Recruiting now Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study follows 403 adults with primary hyperparathyroidism who are having their overactive parathyroid gland removed. Researchers will track heart problems, cholesterol, blood sugar, artery stiffness, and quality of life for up to 5 years after surgery. The goal is to understand whether parathyroidectomy improves overall health beyond just fixing calcium levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could clarify whether parathyroidectomy improves long-term heart, kidney, and bone health in people with primary hyperparathyroidism.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients, and benefits of surgery remain uncertain.

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Conditions

The condition(s) this trial relates to.

primary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY HYPERPARATHYROIDISM

Contacts and locations

Locations

Nantes University Hospital
RECRUITING

Nantes, Loire-Atlantique, 44093, France

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