New drug combo aims to beat back leukemia relapse after transplant
NCT ID NCT05917405
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether replacing fludarabine with clofarabine in the chemotherapy given before a stem cell transplant can help more adults with acute myeloid leukemia (AML) stay alive longer. About 302 patients whose AML is in remission will be randomly assigned to one of two reduced-intensity chemo regimens. The goal is to see if the clofarabine-based regimen improves two-year survival compared to the standard fludarabine-based regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Clofarabine and Busulfan (compared to Fludarabine and Busulfan)
What this could lead to
If clofarabine works better, this could lead to a new standard pre-transplant regimen that lowers relapse risk and improves survival for AML patients.
What could go wrong
This is a mid-stage trial with 302 participants, so results are not yet proven. Clofarabine may cause more side effects, and the survival benefit may not hold up in larger studies.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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APHP Créteil
RECRUITINGCréteil, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHRU Lille
NOT_YET_RECRUITINGLille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHRU Nancy
RECRUITINGNancy, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Amiens
RECRUITINGAmiens, France
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CHU Angers
RECRUITINGAngers, France
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CHU Besançon
RECRUITINGBesançon, France
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CHU Bordeaux
NOT_YET_RECRUITINGBordeaux, France
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CHU Brest
RECRUITINGBrest, France
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CHU Clermont-Ferrand
RECRUITINGClermont-Ferrand, France
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CHU Grenoble
RECRUITINGGrenoble, France
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CHU Limoges
RECRUITINGLimoges, France
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CHU Lyon
RECRUITINGLyon, France
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CHU Montpellier
RECRUITINGMontpellier, France
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CHU Paris St-Louis
RECRUITINGParis, France
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CHU Poitiers
NOT_YET_RECRUITINGPoitiers, France
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CHU Rennes
RECRUITINGRennes, France
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CHU St-Etienne
RECRUITINGSaint-Etienne, France
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CHU de Nantes
RECRUITINGNantes, Loire Atlantique, 44000, France
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CRLC Caen
RECRUITINGCaen, France
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CRLC Toulouse
RECRUITINGToulouse, France
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Institut Paoli Calmettes
RECRUITINGMarseille, France
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Pitie-Salpetriere, APHP
RECRUITINGParis, France
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St-Antoine, APHP
RECRUITINGParis, France
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