New drug combo aims to beat back leukemia relapse after transplant

NCT ID NCT05917405

Recruiting now Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether replacing fludarabine with clofarabine in the chemotherapy given before a stem cell transplant can help more adults with acute myeloid leukemia (AML) stay alive longer. About 302 patients whose AML is in remission will be randomly assigned to one of two reduced-intensity chemo regimens. The goal is to see if the clofarabine-based regimen improves two-year survival compared to the standard fludarabine-based regimen.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clofarabine and Busulfan (compared to Fludarabine and Busulfan)
What this could lead to: If clofarabine works better, this could lead to a new standard pre-transplant regimen that lowers relapse risk and improves survival for AML patients.
What could go wrong: This is a mid-stage trial with 302 participants, so results are not yet proven. Clofarabine may cause more side effects, and the survival benefit may not hold up in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA IN REMISSION

Contacts and locations

Locations

APHP Créteil
RECRUITING

Créteil, France
CHRU Lille
NOT_YET_RECRUITING

Lille, France
CHRU Nancy
RECRUITING

Nancy, France
CHU Amiens
RECRUITING

Amiens, France
CHU Angers
RECRUITING

Angers, France
CHU Besançon
RECRUITING

Besançon, France
CHU Bordeaux
NOT_YET_RECRUITING

Bordeaux, France
CHU Brest
RECRUITING

Brest, France
CHU Clermont-Ferrand
RECRUITING

Clermont-Ferrand, France
CHU Grenoble
RECRUITING

Grenoble, France
CHU Limoges
RECRUITING

Limoges, France
CHU Lyon
RECRUITING

Lyon, France
CHU Montpellier
RECRUITING

Montpellier, France
CHU Paris St-Louis
RECRUITING

Paris, France
CHU Poitiers
NOT_YET_RECRUITING

Poitiers, France
CHU Rennes
RECRUITING

Rennes, France
CHU St-Etienne
RECRUITING

Saint-Etienne, France
CHU de Nantes
RECRUITING

Nantes, Loire Atlantique, 44000, France
CRLC Caen
RECRUITING

Caen, France
CRLC Toulouse
RECRUITING

Toulouse, France
Institut Paoli Calmettes
RECRUITING

Marseille, France
Pitie-Salpetriere, APHP
RECRUITING

Paris, France
St-Antoine, APHP
RECRUITING

Paris, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.